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A new implication of quasispecies dynamics: Broad virus diversification in absence of external perturbations

RNA genetic elements include many important animal and plant pathogens. They share high mutability, a trait that has multiple implications for the interactions with their host organisms. Here we review evidence of a new adaptive feature of RNA viruses that we term “broadly diversifying selection”. I...

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Published in:Infection, genetics and evolution genetics and evolution, 2020-08, Vol.82, p.104278-104278, Article 104278
Main Authors: Domingo, Esteban, Soria, María Eugenia, Gallego, Isabel, de Ávila, Ana Isabel, García-Crespo, Carlos, Martínez-González, Brenda, Gómez, Jordi, Briones, Carlos, Gregori, Josep, Quer, Josep, Perales, Celia
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cited_by cdi_FETCH-LOGICAL-c362t-48841462c5f905f6c18da719fc141ce0225b956dfa5dc242b806bcf93012d7fa3
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container_title Infection, genetics and evolution
container_volume 82
creator Domingo, Esteban
Soria, María Eugenia
Gallego, Isabel
de Ávila, Ana Isabel
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Briones, Carlos
Gregori, Josep
Quer, Josep
Perales, Celia
description RNA genetic elements include many important animal and plant pathogens. They share high mutability, a trait that has multiple implications for the interactions with their host organisms. Here we review evidence of a new adaptive feature of RNA viruses that we term “broadly diversifying selection”. It constitutes a new type of positive selection without participation of any external selective agent, and which is built upon a progressive increase of the number of different genomes that dominate the population. The evidence was provided by analyses of mutant spectrum composition of two important viral pathogens, foot-and-mouth disease virus (FMDV) and hepatitis C virus (HCV) after prolonged replication in their respective cell culture environment. Despite being fueled by mutations that arise randomly and in absence of an external guiding selective force, this type of selection prepares the viral population for a response to selective forces still to occur. Since current evidence suggests that broadly diversifying selection is favored by elevated mutation rates and population sizes, it may constitute a more general behavior, relevant also to the adaptive dynamics of microbial populations and cancer cells. •A new class of positive selection for RNA viruses is described.•It may apply to microbial communities characterized by large population sizes and high error rates.•It provides a new adaptive strategy derived from quasispecies dynamics.
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subjects Adaptive strategies
Foot-and-mouth disease virus
Hepatitis C virus
Mutational waves
RNA viruses
Selective forces
title A new implication of quasispecies dynamics: Broad virus diversification in absence of external perturbations
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