Antitumor activity of nervosine VII, and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells

Nervosine VII is one of the known saturated pyrrolizidine alkaloids isolated from the plant of Liparis nervosa. This is first study to investigate the antitumor activity of nervosine VII in vitro, and the results indicated that nervosine VII induced autophagy and apoptosis in HCT116 human colorectal...

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Published in:Chinese journal of natural medicines 2020-02, Vol.18 (2), p.81-89
Main Authors: HUANG, Shuai, ZHAO, Shuang-Mei, SHAN, Lian-Hai, ZHOU, Xian-Li
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Autophagy
Autophagy - drug effects
HCT116 Cells
Humans
Liparis nervosa
Nervosine VII
Orchidaceae - chemistry
Plant Extracts - pharmacology
Pyrrolizidine alkaloids
Pyrrolizidine Alkaloids - pharmacology
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Summary:Nervosine VII is one of the known saturated pyrrolizidine alkaloids isolated from the plant of Liparis nervosa. This is first study to investigate the antitumor activity of nervosine VII in vitro, and the results indicated that nervosine VII induced autophagy and apoptosis in HCT116 human colorectal cancer cells. Mechanistic studies showed that nervosine VII-induced apoptosis was associated with the intrinsic pathway by the activation of caspase-9, −3 and −7. Autophagy induced by nervosine VII was characteristic with the regulation of autophagic markers including the increase of LC3-II and beclin 1 proteins, and the decrease of p62 protein. Nervosine VII simultaneously induced autophagy and apoptosis by activated MAPKs signaling pathway including JNK, ERK1/2 and p38, suppressing the p53 signaling pathway.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(20)30009-1