Porcine cytochrome P450 3A: current status on expression and regulation

The cytochrome P450s (CYPs) constitute a family of enzymes maintaining vital functions in the body and are mostly recognized for their significant role in detoxification. Of the CYP subfamilies, CYP3A, is one of the most active in the clearance of drugs and other xenobiotics. During the last decades...

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Bibliographic Details
Published in:Archives of toxicology 2020-06, Vol.94 (6), p.1899-1914
Main Author: Rasmussen, Martin Krøyer
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cytochrome
Cytochrome P450
Cytochromes P450
Detoxification
Environmental Health
Occupational Medicine/Industrial Medicine
Pharmacology/Toxicology
Regulations
Review Article
Xenobiotics
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Summary:The cytochrome P450s (CYPs) constitute a family of enzymes maintaining vital functions in the body and are mostly recognized for their significant role in detoxification. Of the CYP subfamilies, CYP3A, is one of the most active in the clearance of drugs and other xenobiotics. During the last decades, much focus has been on exploring different models for human CYP3A regulation, expression and activity. In that respect, the growing knowledge of the porcine CYP3As is of great interest. Although many aspects of porcine CYP3A regulation and activity are still unknown, the current literature provides a basic understanding of the porcine CYP3As that can be used e.g., when translating results from studies done in the porcine model into human settings. In this review, the current knowledge about porcine CYP3A expression, regulation, activity and metabolic significance are highlighted. Future research needs are also identified.
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-020-02710-9