Photopolymerized Starchstarch Nanoparticle (SNP) network hydrogels

•Methacrylated starch nanoparticles (SNPs) form hydrogels via photopolymerization.•Stiffer and denser hydrogels can be formed with SNPs relative to linear starch.•SNP hydrogel properties are governed by both inter- and intra-particle crosslinks.•SNP hydrogels resist cell adhesion while remaining hig...

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Bibliographic Details
Published in:Carbohydrate polymers 2020-05, Vol.236, p.115998-115998, Article 115998
Main Authors: Majcher, Michael J., McInnis, Carter L., Himbert, Sebastian, Alsop, Richard J., Kinio, Dennis, Bleuel, Markus, Rheinstädter, Maikel C., Smeets, Niels M.B., Hoare, Todd
Format: Article
Language:English
Subjects:
Biopolymer
Hydrogel
Nanoparticle
Photopolymerization
Starch
Sustainable materials
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Summary:•Methacrylated starch nanoparticles (SNPs) form hydrogels via photopolymerization.•Stiffer and denser hydrogels can be formed with SNPs relative to linear starch.•SNP hydrogel properties are governed by both inter- and intra-particle crosslinks.•SNP hydrogels resist cell adhesion while remaining highly cytocompatible. Starch is an attractive biomaterial given its low cost and high protein repellency, but its use in forming functional hydrogels is limited by its high viscosity and crystallinity. Herein, we demonstrate the use of fully amorphous starch nanoparticles (SNPs) as functional hydrogel building blocks that overcome these challenges. Methacrylation of SNPs enables hydrogel formation via photopolymerization, with the low viscosity of SNPs enabling facile preparation of pre-gel suspensions of up to 35 wt% SNPs relative to
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2020.115998