Long-term health-related quality of life after surgery in patients with chronic thromboembolic pulmonary hypertension

• Published in: Quality of life research 2020-08, Vol.29 (8), p.2111-2118
• Main Authors: Kamenskaya, Oksana, Klinkova, Asya, Chernyavskiy, Aleksander, Lomivorotov, Vladimir V., Edemskiy, Alexander, Shmyrev, Vladimir
• Format: Article
• Language: English
• Subjects: Age; Comorbidity; Medicine; Medicine & Public Health; Public Health; Pulmonary hypertension; Quality of life; Quality of Life Research; Sociology; Surgery; Thromboembolism
• ISSN: 0962-9343; 1573-2649
• DOI: 10.1007/s11136-020-02471-z

Purpose To assess the dynamic of various health-related quality of life (HRQoL) parameters 3 years after pulmonary thromboendarterectomy (PTE), and to identify factors affecting HRQoL parameters in patients with chronic thromboembolic pulmonary hypertension (CTEPH) in the long-term follow-up after surgery. Methods This prospective cohort study included 128 patients with CTEPH before and after the PTE (3 year follow-up). The HRQoL was examined using the Short-Form 36 Health Survey Questionnaire (SF-36). Results In patients with CTEPH 3 years after PTE, a significant improvement in all the HRQoL parameters. The summary indicators of the physical and mental components of health remained at the same level as 1 year after the PTE and did not exceed 50 points. The residual pulmonary hypertension was a leading factor limiting parameters of physical and mental health 3 years after a PTE. In addition, the parameters of physical activity were adversely affected by age and the age-adjusted Charlson Comorbidity Index. Conclusions In the study group of patients with CTEPH, PTE contributes to a significant improvement in all HRQoL parameters, which observed both 1 year and 3 years after surgery. The leading factor adversely affecting the physical and emotional components of health in the long-term period after PTE was residual pulmonary hypertension recorded in the early postoperative period. In addition, some physical HRQoL parameters are affected by age and age-adjusted Charlson Comorbidity Index.