Single‐Cell RNA Sequencing in Hematological Diseases

Hematological diseases, including leukemia, lymphoma, and multiple myeloma, are characterized by high heterogeneity with diverse cellular subpopulations. Single‐cell RNA sequencing (scRNA‐seq), a transformational technology, provides deep insights into cell‐to‐cell variation in tumor and microenviro...

Full description

Saved in:
Bibliographic Details
Published in:Proteomics (Weinheim) 2020-07, Vol.20 (13), p.e1900228-n/a
Main Authors: Zhu, Yue, Huang, Yaohui, Tan, Yun, Zhao, Weili, Tian, Qiang
Format: Article
Language:English
Subjects:
cellular indexing of transcriptomes and epitopes by sequencing
Gene sequencing
Hematological diseases
hematological malignancy
Hematology
Heterogeneity
Leukemia
Lymphoma
Multiple myeloma
Pathogenesis
Ribonucleic acid
RNA
single‐cell analysis
single‐cell RNA sequencing
Subpopulations
Transcriptomics
Utilities
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hematological diseases, including leukemia, lymphoma, and multiple myeloma, are characterized by high heterogeneity with diverse cellular subpopulations. Single‐cell RNA sequencing (scRNA‐seq), a transformational technology, provides deep insights into cell‐to‐cell variation in tumor and microenvironment, allows high‐resolution dissection of the pathogenic mechanisms of diseases, and affords potential clinical utilities. Recent developments in single‐cell transcriptomics and associated technologies and their applications in hematological disorders for unraveling cellular subpopulations, disease pathogenesis, patient stratification, and therapeutic responses are summarized.
ISSN:1615-9853
1615-9861
DOI:10.1002/pmic.201900228