Herbal formulation “turmeric extract, black pepper, and ginger” versus Naproxen for chronic knee osteoarthritis: A randomized, double‐blind, controlled clinical trial

Osteoarthritis is the most common articular disease that can lead to chronic pain and severe disability. Curcumin—an effective ingredient in turmeric with anti inflammatory property—plays an important role in protecting the joints against destructive factors. Gingerols and piperine, are the effectiv...

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Bibliographic Details
Published in:Phytotherapy research 2020-08, Vol.34 (8), p.2067-2073
Main Authors: Heidari‐Beni, Motahar, Moravejolahkami, Amir R., Gorgian, Pegah, Askari, Gholamreza, Tarrahi, Mohammad J., Bahreini‐Esfahani, Nimah
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis
Biomedical materials
black pepper
Chronic Disease
Chronic pain
Curcuma - chemistry
Curcumin
Curcumin - chemistry
Double-Blind Method
Double-blind studies
Female
Ginger
Humans
Inflammation
Joint diseases
Knee
knee osteoarthritis
Male
Middle Aged
Naproxen
Naproxen - pharmacology
Naproxen - therapeutic use
Osteoarthritis
Osteoarthritis, Knee - drug therapy
Pain
Piper nigrum
Piper nigrum - chemistry
Piperine
Plant Extracts - chemistry
Prostaglandin E2
turmeric extract
Zingiber officinale - chemistry
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Summary:Osteoarthritis is the most common articular disease that can lead to chronic pain and severe disability. Curcumin—an effective ingredient in turmeric with anti inflammatory property—plays an important role in protecting the joints against destructive factors. Gingerols and piperine, are the effective ingredients of ginger and black pepper, which may potentially enhance and sustain the effect of curcumin in this direction. To determine the effect of cosupplementation with turmeric extract, black pepper, and ginger on prostaglandin E2 (PGE2) in patients with chronic knee osteoarthritis, compared with Naproxen. Sixty patients with two different levels of knee osteoarthritis (Grade 2 and 3) were studied. Individuals were randomly assigned to receive daily turmeric extract, ginger, and black pepper together or Naproxen capsule for 4 weeks. PGE2 was evaluated by ELISA method. 24‐hr recall was also assessed. All of participants completed the study. PGE2 decreased significantly in both groups (p
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.6671