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Evaluation of the role of ultrasound biomicroscopy in advanced retinoblastoma: A prospective study on Asian Indian children
: To evaluate the role of ultrasound biomicroscopy (UBM) in retinoblastoma (RB). : Children with advanced unilateral RB were included. UBM was performed to look for tumour invasion into the anterior segment (AS) and for evaluation of quantitative parameters. Enucleation was done and UBM findings wer...
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| Published in: | Ophthalmic genetics 2020-03, Vol.41 (2), p.125-130 |
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| cites | cdi_FETCH-LOGICAL-c309t-a4d9020f5fcdbbd0f1bd42ec4e304e31416b9dc2175372f8e5a1e4b41f7ea583 |
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| container_title | Ophthalmic genetics |
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| creator | Chawla, Bhavna Bhaskaran, Karthika Dada, Tanuj Bajaj, Mandeep S Kashyap, Seema Shende, Dilip |
| description | : To evaluate the role of ultrasound biomicroscopy (UBM) in retinoblastoma (RB).
: Children with advanced unilateral RB were included. UBM was performed to look for tumour invasion into the anterior segment (AS) and for evaluation of quantitative parameters. Enucleation was done and UBM findings were correlated with histopathology. The main outcome measures were sensitivity and specificity of UBM for detecting AS invasion and comparison of quantitative parameters between the tumour affected and fellow eyes.
: Fifty patients were evaluated. The mean age was 2.76 ± 1.63 years. Enucleation was performed in 50 eyes. The sensitivity and specificity of UBM for AS invasion were 80% (95% CI, 44-97%) and 95% (95% CI, 83-99%), respectively. UBM showed a sensitivity and specificity of 100% (95% CI, 59-100%) and 95% (95% CI, 84-99%), respectively, for iris invasion, 88% (95% CI, 47-100%) and 100% (95% CI, 92-100%), respectively, for ciliary body invasion, and 63% (95% CI, 24-91%) and 100% (95% CI, 92-100%), respectively, for anterior chamber (AC) angle invasion. Quantitative parameters were studied in 100 eyes. As compared to the fellow eyes, the AC angle was narrow ( |
| doi_str_mv | 10.1080/13816810.2020.1737946 |
| format | article |
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: Children with advanced unilateral RB were included. UBM was performed to look for tumour invasion into the anterior segment (AS) and for evaluation of quantitative parameters. Enucleation was done and UBM findings were correlated with histopathology. The main outcome measures were sensitivity and specificity of UBM for detecting AS invasion and comparison of quantitative parameters between the tumour affected and fellow eyes.
: Fifty patients were evaluated. The mean age was 2.76 ± 1.63 years. Enucleation was performed in 50 eyes. The sensitivity and specificity of UBM for AS invasion were 80% (95% CI, 44-97%) and 95% (95% CI, 83-99%), respectively. UBM showed a sensitivity and specificity of 100% (95% CI, 59-100%) and 95% (95% CI, 84-99%), respectively, for iris invasion, 88% (95% CI, 47-100%) and 100% (95% CI, 92-100%), respectively, for ciliary body invasion, and 63% (95% CI, 24-91%) and 100% (95% CI, 92-100%), respectively, for anterior chamber (AC) angle invasion. Quantitative parameters were studied in 100 eyes. As compared to the fellow eyes, the AC angle was narrow (
< 0.05), posterior chamber was shallow (
= 0.004) and zonular length was increased (
= 0.001) in RB eyes.
: This clinicopathological study provides valuable insights into the role of UBM for evaluation of anterior extension of RB and for assessment of architectural changes in the AS due to the tumour.</description><identifier>ISSN: 1381-6810</identifier><identifier>EISSN: 1744-5094</identifier><identifier>DOI: 10.1080/13816810.2020.1737946</identifier><identifier>PMID: 32176559</identifier><language>eng</language><publisher>England</publisher><subject>Child, Preschool ; Female ; Humans ; India - epidemiology ; Male ; Microscopy, Acoustic - methods ; Prospective Studies ; Retinal Neoplasms - diagnostic imaging ; Retinal Neoplasms - epidemiology ; Retinal Neoplasms - pathology ; Retinoblastoma - diagnostic imaging ; Retinoblastoma - epidemiology ; Retinoblastoma - pathology</subject><ispartof>Ophthalmic genetics, 2020-03, Vol.41 (2), p.125-130</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-a4d9020f5fcdbbd0f1bd42ec4e304e31416b9dc2175372f8e5a1e4b41f7ea583</citedby><cites>FETCH-LOGICAL-c309t-a4d9020f5fcdbbd0f1bd42ec4e304e31416b9dc2175372f8e5a1e4b41f7ea583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32176559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chawla, Bhavna</creatorcontrib><creatorcontrib>Bhaskaran, Karthika</creatorcontrib><creatorcontrib>Dada, Tanuj</creatorcontrib><creatorcontrib>Bajaj, Mandeep S</creatorcontrib><creatorcontrib>Kashyap, Seema</creatorcontrib><creatorcontrib>Shende, Dilip</creatorcontrib><title>Evaluation of the role of ultrasound biomicroscopy in advanced retinoblastoma: A prospective study on Asian Indian children</title><title>Ophthalmic genetics</title><addtitle>Ophthalmic Genet</addtitle><description>: To evaluate the role of ultrasound biomicroscopy (UBM) in retinoblastoma (RB).
: Children with advanced unilateral RB were included. UBM was performed to look for tumour invasion into the anterior segment (AS) and for evaluation of quantitative parameters. Enucleation was done and UBM findings were correlated with histopathology. The main outcome measures were sensitivity and specificity of UBM for detecting AS invasion and comparison of quantitative parameters between the tumour affected and fellow eyes.
: Fifty patients were evaluated. The mean age was 2.76 ± 1.63 years. Enucleation was performed in 50 eyes. The sensitivity and specificity of UBM for AS invasion were 80% (95% CI, 44-97%) and 95% (95% CI, 83-99%), respectively. UBM showed a sensitivity and specificity of 100% (95% CI, 59-100%) and 95% (95% CI, 84-99%), respectively, for iris invasion, 88% (95% CI, 47-100%) and 100% (95% CI, 92-100%), respectively, for ciliary body invasion, and 63% (95% CI, 24-91%) and 100% (95% CI, 92-100%), respectively, for anterior chamber (AC) angle invasion. Quantitative parameters were studied in 100 eyes. As compared to the fellow eyes, the AC angle was narrow (
< 0.05), posterior chamber was shallow (
= 0.004) and zonular length was increased (
= 0.001) in RB eyes.
: This clinicopathological study provides valuable insights into the role of UBM for evaluation of anterior extension of RB and for assessment of architectural changes in the AS due to the tumour.</description><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Male</subject><subject>Microscopy, Acoustic - methods</subject><subject>Prospective Studies</subject><subject>Retinal Neoplasms - diagnostic imaging</subject><subject>Retinal Neoplasms - epidemiology</subject><subject>Retinal Neoplasms - pathology</subject><subject>Retinoblastoma - diagnostic imaging</subject><subject>Retinoblastoma - epidemiology</subject><subject>Retinoblastoma - pathology</subject><issn>1381-6810</issn><issn>1744-5094</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNo9kE1PwzAMhiMEYmPwE0A5cikkTdIPbtM0YNIkLrtXaeJqQW1SmnTSxJ8n1TYOlh3rtZ33QeiRkhdKCvJKWUGzIr5SksZWzvKSZ1doTnPOE0FKfh3rqEkm0Qzdef9NSJpSKm7RjKU0z4Qo5-h3fZDtKINxFrsGhz3gwbUw1WMbBundaDWujeuMGpxXrj9iY7HUB2kVaDxAMNbVrfTBdfINL3EfZT2oYA6AfRj1EcfVS2-kxRurp6T2ptUD2Ht008jWw8M5L9Dufb1bfSbbr4_NarlNFCNlSCTXZfTYiEbputakobXmKSgOjMSgnGZ1qVW0JFieNgUISYHXnDY5SFGwBXo-rY0_-xnBh6ozXkHbSgtu9FXK8oKQnJQsSsVJOnn1AzRVP5hODseKkmrCXl2wVxP26ow9zj2dT4x1B_p_6sKZ_QHUnX_1</recordid><startdate>20200303</startdate><enddate>20200303</enddate><creator>Chawla, Bhavna</creator><creator>Bhaskaran, Karthika</creator><creator>Dada, Tanuj</creator><creator>Bajaj, Mandeep S</creator><creator>Kashyap, Seema</creator><creator>Shende, Dilip</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200303</creationdate><title>Evaluation of the role of ultrasound biomicroscopy in advanced retinoblastoma: A prospective study on Asian Indian children</title><author>Chawla, Bhavna ; Bhaskaran, Karthika ; Dada, Tanuj ; Bajaj, Mandeep S ; Kashyap, Seema ; Shende, Dilip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-a4d9020f5fcdbbd0f1bd42ec4e304e31416b9dc2175372f8e5a1e4b41f7ea583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Male</topic><topic>Microscopy, Acoustic - methods</topic><topic>Prospective Studies</topic><topic>Retinal Neoplasms - diagnostic imaging</topic><topic>Retinal Neoplasms - epidemiology</topic><topic>Retinal Neoplasms - pathology</topic><topic>Retinoblastoma - diagnostic imaging</topic><topic>Retinoblastoma - epidemiology</topic><topic>Retinoblastoma - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chawla, Bhavna</creatorcontrib><creatorcontrib>Bhaskaran, Karthika</creatorcontrib><creatorcontrib>Dada, Tanuj</creatorcontrib><creatorcontrib>Bajaj, Mandeep S</creatorcontrib><creatorcontrib>Kashyap, Seema</creatorcontrib><creatorcontrib>Shende, Dilip</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmic genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chawla, Bhavna</au><au>Bhaskaran, Karthika</au><au>Dada, Tanuj</au><au>Bajaj, Mandeep S</au><au>Kashyap, Seema</au><au>Shende, Dilip</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the role of ultrasound biomicroscopy in advanced retinoblastoma: A prospective study on Asian Indian children</atitle><jtitle>Ophthalmic genetics</jtitle><addtitle>Ophthalmic Genet</addtitle><date>2020-03-03</date><risdate>2020</risdate><volume>41</volume><issue>2</issue><spage>125</spage><epage>130</epage><pages>125-130</pages><issn>1381-6810</issn><eissn>1744-5094</eissn><abstract>: To evaluate the role of ultrasound biomicroscopy (UBM) in retinoblastoma (RB).
: Children with advanced unilateral RB were included. UBM was performed to look for tumour invasion into the anterior segment (AS) and for evaluation of quantitative parameters. Enucleation was done and UBM findings were correlated with histopathology. The main outcome measures were sensitivity and specificity of UBM for detecting AS invasion and comparison of quantitative parameters between the tumour affected and fellow eyes.
: Fifty patients were evaluated. The mean age was 2.76 ± 1.63 years. Enucleation was performed in 50 eyes. The sensitivity and specificity of UBM for AS invasion were 80% (95% CI, 44-97%) and 95% (95% CI, 83-99%), respectively. UBM showed a sensitivity and specificity of 100% (95% CI, 59-100%) and 95% (95% CI, 84-99%), respectively, for iris invasion, 88% (95% CI, 47-100%) and 100% (95% CI, 92-100%), respectively, for ciliary body invasion, and 63% (95% CI, 24-91%) and 100% (95% CI, 92-100%), respectively, for anterior chamber (AC) angle invasion. Quantitative parameters were studied in 100 eyes. As compared to the fellow eyes, the AC angle was narrow (
< 0.05), posterior chamber was shallow (
= 0.004) and zonular length was increased (
= 0.001) in RB eyes.
: This clinicopathological study provides valuable insights into the role of UBM for evaluation of anterior extension of RB and for assessment of architectural changes in the AS due to the tumour.</abstract><cop>England</cop><pmid>32176559</pmid><doi>10.1080/13816810.2020.1737946</doi><tpages>6</tpages></addata></record> |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Child, Preschool Female Humans India - epidemiology Male Microscopy, Acoustic - methods Prospective Studies Retinal Neoplasms - diagnostic imaging Retinal Neoplasms - epidemiology Retinal Neoplasms - pathology Retinoblastoma - diagnostic imaging Retinoblastoma - epidemiology Retinoblastoma - pathology |
| title | Evaluation of the role of ultrasound biomicroscopy in advanced retinoblastoma: A prospective study on Asian Indian children |
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