Protease inhibitor effects on prevalence of bacterial vaginosis and human papillomavirus‐related lesions

Aim Antiretrovirals of the protease inhibitor (PI) class tend to achieve low concentrations in biological fluids. This study aimed to analyze possible changes in the vaginal microbiome and frequency of cervical human papillomavirus (HPV)‐DNA and HPV‐related lesions associated with the use of PI in a...

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Bibliographic Details
Published in:The journal of obstetrics and gynaecology research 2020-06, Vol.46 (6), p.899-906
Main Authors: Marques, Marcos P. C., Pinto, Amanda C., Soares, Leila C., Macedo, Jacyara M. B., dos Santos, Débora F., Oliveira, Marco A. P.
Format: Article
Language:English
Subjects:
Adult
Antiretroviral drugs
Antiretroviral therapy
Antiretroviral Therapy, Highly Active - methods
Antiviral agents
benign disease of vulva and vagina
Brazil
CD4 antigen
Cross-Sectional Studies
cytology and gynecologic pathology
Cytopathology
Deoxyribonucleic acid
DNA
Female
HIV
HIV Infections - complications
HIV Infections - drug therapy
Human immunodeficiency virus
Human papillomavirus
human papillomavirus infection and cervical intraepithelial neoplasia
Humans
Lesions
Microbiomes
Microbiota - drug effects
Middle Aged
Papillomavirus Infections - complications
Polymerase chain reaction
Prospective Studies
Protease Inhibitors - administration & dosage
Proteinase inhibitors
Vagina
Vagina - drug effects
Vaginosis
Vaginosis, Bacterial - microbiology
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Summary:Aim Antiretrovirals of the protease inhibitor (PI) class tend to achieve low concentrations in biological fluids. This study aimed to analyze possible changes in the vaginal microbiome and frequency of cervical human papillomavirus (HPV)‐DNA and HPV‐related lesions associated with the use of PI in antiretroviral therapy (ART). Methods Eighty‐eight women with human immunodeficiency virus infection were divided in two groups: ART with PI and without PI. All the participants underwent anamnesis with demographic data collection. The total DNA, used as the template in the polymerase chain reaction‐based assays for the detection of HPV‐DNA, was extracted from cervical samples during cervical cytopathology. Results There were no differences between the groups with respect to HPV‐related lesions. Despite the higher prevalence of bacterial vaginosis (BV) in the PI group (33.96% vs 17.14%), the difference was insignificant when considering all women (P = 0.066). When women with a detectable viral load and a CD4+ T‐cell count
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.14245