Prediction of S-1 adjuvant chemotherapy benefit in Stage II/III gastric cancer treatment based on comprehensive gene expression analysis

Background Studies to identify predictive biomarkers of adjuvant chemotherapy with S-1 after gastrectomy in Stage II/III gastric cancer patients have been done; however, more clarity and understanding are needed. Our aim in the present study was to identify biomarkers predicting benefit due to S-1 a...

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Published in:Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2020-07, Vol.23 (4), p.648-658
Main Authors: Nakamura, Kenichi, Hatakeyama, Keiichi, Furukawa, Kenichiro, Fujiya, Keiichi, Kamiya, Satoshi, Hikage, Makoto, Tanizawa, Yutaka, Bando, Etsuro, Ohshima, Keiichi, Urakami, Kenichi, Machida, Nozomu, Yasui, Hirofumi, Yamaguchi, Ken, Terashima, Masanori
Format: Article
Language:English
Subjects:
Abdominal Surgery
Biomarkers
Cancer Research
Cancer therapies
Chemotherapy
DNA microarrays
Gastrectomy
Gastric cancer
Gastroenterology
Gene expression
Medicine
Medicine & Public Health
Oncology
Original Article
Surgical Oncology
Survival
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Summary:Background Studies to identify predictive biomarkers of adjuvant chemotherapy with S-1 after gastrectomy in Stage II/III gastric cancer patients have been done; however, more clarity and understanding are needed. Our aim in the present study was to identify biomarkers predicting benefit due to S-1 adjuvant chemotherapy using comprehensive gene expression analysis. Methods We retrospectively analyzed 102 patients receiving adjuvant chemotherapy with S-1 and 46 patients not receiving S-1 adjuvant chemotherapy after gastrectomy for gastric cancer treatment between January 2014 and December 2016. Hierarchical clustering analysis was performed based on the gene expression data obtained using cDNA microarray. Differentially expressed genes (DEGs) were identified using thresholds of absolute fold changes of > 4.0 and a false discovery rate P value of 
ISSN:1436-3291
1436-3305
DOI:10.1007/s10120-020-01056-6