A Tuft Act to Follow: Leukotrienes Take the Stage in Anti-worm Immunity

Tuft cells are specialized taste-chemosensory cells that detect the presence of intestinal parasites and orchestrate type 2 immunity. In this issue of Immunity, McGinty et al. discover that parasitic worms, but not commensal protists, stimulate tuft cells to release cysteinyl leukotrienes to amplify...

Full description

Saved in:
Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2020-03, Vol.52 (3), p.426-428
Main Authors: Fung, Connie, Howitt, Michael R.
Format: Article
Language:English
Subjects:
Animals
Bone marrow
Chemoreception
Helminths
Hyperplasia
Immunity
Infections
Intestinal Mucosa
Intestinal parasites
Intestine
Intestine, Small
Leukotrienes
Mebendazole
Parasites
Small intestine
Worms
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tuft cells are specialized taste-chemosensory cells that detect the presence of intestinal parasites and orchestrate type 2 immunity. In this issue of Immunity, McGinty et al. discover that parasitic worms, but not commensal protists, stimulate tuft cells to release cysteinyl leukotrienes to amplify anti-helminth immunity in the small intestine. Tuft cells are specialized taste-chemosensory cells that detect the presence of intestinal parasites and orchestrate type 2 immunity. In this issue of Immunity, McGinty et al. discover that parasitic worms, but not commensal protists, stimulate tuft cells to release cysteinyl leukotrienes to amplify anti-helminth immunity in the small intestine.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2020.02.011