Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4 + T cell recovery can harbor replication-competent HIV despite viral suppression

In addition to hemostasis, human platelets have several immune functions and interact with infectious pathogens including HIV in vitro. Here, we report that platelets from HIV-infected individuals on combined antiretroviral drug therapy (ART) with low blood CD4 T cell counts (

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Bibliographic Details
Published in:Science translational medicine 2020-03, Vol.12 (535)
Main Authors: Real, Fernando, Capron, Claude, Sennepin, Alexis, Arrigucci, Riccardo, Zhu, Aiwei, Sannier, Gérémy, Zheng, Jonathan, Xu, Lin, Massé, Jean-Marc, Greffe, Ségolène, Cazabat, Michelle, Donoso, Maribel, Delobel, Pierre, Izopet, Jacques, Eugenin, Eliseo, Gennaro, Maria Laura, Rouveix, Elisabeth, Cramer Bordé, Elisabeth, Bomsel, Morgane
Format: Article
Language:English
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Summary:In addition to hemostasis, human platelets have several immune functions and interact with infectious pathogens including HIV in vitro. Here, we report that platelets from HIV-infected individuals on combined antiretroviral drug therapy (ART) with low blood CD4 T cell counts (
ISSN:1946-6234
1946-6242
DOI:10.1126/scitranslmed.aat6263