Progresses on bacterial secretomes enlighten research on Mycoplasma secretome

Bacterial secretome is a comprehensive catalog of bacterial proteins that are released or secreted outside the cells. They offer a number of factors that possess several significant roles in virulence as well as cell to cell communication and hence play a core role in bacterial pathogenesis. Sometim...

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Bibliographic Details
Published in:Microbial pathogenesis 2020-07, Vol.144, p.104160-104160, Article 104160
Main Authors: Zubair, Muhammad, Khan, Farhan Anwar, Menghwar, Harish, Faisal, Muhammad, Ashraf, Muhammad, Rasheed, Muhammad Asif, Marawan, Marawan A., Dawood, Ali, Chen, Yingyu, Chen, Huanchun, Guo, Aizhen
Format: Article
Language:English
Subjects:
Antigens
Bacteria
Bacterial Outer Membrane - physiology
Extracellular vesicles
Extracellular Vesicles - physiology
Mycoplasma
Mycoplasma - metabolism
Mycoplasma - pathogenicity
Pathogenesis
Protein Transport - physiology
Proteome - metabolism
Quorum Sensing - physiology
Secretomes
Signal Transduction - physiology
Virulence Factors - metabolism
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Summary:Bacterial secretome is a comprehensive catalog of bacterial proteins that are released or secreted outside the cells. They offer a number of factors that possess several significant roles in virulence as well as cell to cell communication and hence play a core role in bacterial pathogenesis. Sometimes these proteins are bounded with membranes giving them the shape of vesicles called extracellular vesicles (EVs) or outer membrane vesicles (OMVs). Bacteria secrete these proteins via Sec and Tat pathways into the periplasm. Secreted proteins have found to be important as diagnostic markers as well as antigenic factors for the development of an effective candidate vaccine. Recently, the research in the field of secretomics is growing up and getting more interesting due to their direct involvement in the pathogenesis of the microorganisms leading to the infection. Many pathogenic bacteria have been studied for their secretome and the results illustrated novel antigens. This review highlights the secretome studies of different pathogenic bacteria in humans and animals, general secretion mechanisms, different approaches and challenges in the secretome of Mycoplasma sp. •Bacterial cell secretome.•Mechanisms of Bacterial Secretion.•Challenges in investigating Mycoplasma secretome.•Approaches to explore the secretome of Mycoplasma sp.•Future prospects.
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2020.104160