The changing epidemiology of the ageing thalassaemia populations: A position statement of the Thalassaemia International Federation

Therapeutic advances in β‐thalassaemia have gradually lead to a significant improvement in prognosis over the past few decades. As a result, patients living in areas where disease‐specific programmes offering access to modern therapy are in place experience a new era of prolonged survival that tends...

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Bibliographic Details
Published in:European journal of haematology 2020-07, Vol.105 (1), p.16-23
Main Authors: Farmakis, Dimitrios, Giakoumis, Anastasios, Angastiniotis, Michael, Eleftheriou, Androulla
Format: Article
Language:English
Subjects:
ageing
Aging
Blood diseases
comorbidities
Epidemiology
Medical prognosis
Patients
Prognosis
survival
Thalassaemia
Thalassemia
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Summary:Therapeutic advances in β‐thalassaemia have gradually lead to a significant improvement in prognosis over the past few decades. As a result, patients living in areas where disease‐specific programmes offering access to modern therapy are in place experience a new era of prolonged survival that tends to reach that of the normal population. This ageing thalassaemia population, however, faces a new spectrum of comorbidities resulting from increasing age that may jeopardise the advances in prognosis provided by current therapy and thus poses new challenges in diagnosis, monitoring and treatment. In this position paper of the Thalassaemia International Federation, we review the changing epidemiology and clinical spectrum of patients with β‐thalassaemia and propose actions to be undertaken in order to address the emerging spectrum of comorbidities resulting from ageing.
ISSN:0902-4441
1600-0609
DOI:10.1111/ejh.13410