Bisphenol A, octylphenols and nonylphenols in fish muscle determined by LC/ESI-MS/MS after affinity chromatography clean up

An analytical method is applied to simultaneously determine bisphenol A, 4-octylphenol, 4-tert-octylphenol, 4-nonylphenol and tert-nonylphenol in fish muscle. The method consisted of a cleanup on molecularly imprinted polymers cartridges (MIPs) followed by liquid chromatography coupled to a tandem m...

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Bibliographic Details
Published in:Food additives & contaminants Part B, Surveillance communications Surveillance communications, 2020-06, Vol.13 (2), p.139-147
Main Authors: Di Marco Pisciottano, Ilaria, Mita, Gustavo Damiano, Gallo, Pasquale
Format: Article
Language:English
Subjects:
Bisphenol A
BPA
Cartridges
Chromatography
endocrine disruptor chemicals
Endocrine disruptors
Fish
Imprinted polymers
Liquid chromatography
molecularly imprinted polymers cartridges
Muscles
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Summary:An analytical method is applied to simultaneously determine bisphenol A, 4-octylphenol, 4-tert-octylphenol, 4-nonylphenol and tert-nonylphenol in fish muscle. The method consisted of a cleanup on molecularly imprinted polymers cartridges (MIPs) followed by liquid chromatography coupled to a tandem mass spectrometer. The method is rapid, specific, reliable and very sensitive, allowing for quantification down to 0.5 ng/g for all studied compounds. After in-house validation, the method was employed to monitor the concentration levels of BPA and four target alkylphenols in 44 marine fish, collected from third countries in the frame of official control activities. The results showed that 27 samples (61.4%) were contaminated by at least one target compound. Bisphenol A was determined in 11 samples in the range 0.6-7.1 ng/g, 4-tert-octylphenol in 8 samples (0.5-1.6 ng/g) and tert-nonylphenol in 14 samples (0.8-8.9 ng/g). 4-Octylphenol and 4-nonylphenol were not detected at all.
ISSN:1939-3210
1939-3229
DOI:10.1080/19393210.2020.1740335