Circulating levels of Elabela and Apelin in the second and third trimesters of pregnancies with gestational diabetes mellitus

We design this study to detect levels of Elabela (ELA) and Apelin (APLN) in women with and without gestational diabetes mellitus (GDM) in the second and third trimesters, and to identify whether there is any association between ELA, APLN, and metabolic parameters. Seventy-nine GDM and 80 control sub...

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Bibliographic Details
Published in:Gynecological endocrinology 2020-10, Vol.36 (10), p.890-894
Main Authors: Guo, Yan-Yan, Li, Tong, Liu, Han, Tang, Lin, Li, Yu-Chen, Hu, Hong-Tao, Su, Yun-Fei, Lin, Yu, Wang, Yin-Yu, Li, Cheng, Huang, He-Feng, Jin, Li, Liu, Xin-Mei
Format: Article
Language:English
Subjects:
Apelin
Elabela
Gestational diabetes mellitus
glucose metabolism
lipid metabolism
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Summary:We design this study to detect levels of Elabela (ELA) and Apelin (APLN) in women with and without gestational diabetes mellitus (GDM) in the second and third trimesters, and to identify whether there is any association between ELA, APLN, and metabolic parameters. Seventy-nine GDM and 80 control subjects in the second trimester and 87 GDM and 88 healthy subjects in the third trimester were included. In the second trimester, lower ELA levels [(14.1 versus 16.9) ng/ml, p = .025] and higher APLN levels [(1021.8 versus 923.5) pg/ml, p = .046] were observed in GDM patients compared to controls. ELA levels were positively correlated with fasting plasma glucose (FPG) (r = 0.423, p 
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2020.1739264