Loading…
Diagnostic value of urinary monocyte chemoattractant protein-1 in evaluating the activity of lupus nephritis: a meta-analysis
Objective This study aimed to assess systematically the overall diagnostic value of urinary monocyte chemoattractant protein-1 (uMCP-1) in systemic lupus erythematosus (SLE) patients with active lupus nephritis (LN). Methods Articles from PubMed, Web of Science, EMBASE and Cochrane Library were retr...
Saved in:
| Published in: | Lupus 2020-05, Vol.29 (6), p.599-606 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c431t-50fcad29f400fd19118a5ca5cbd32986906e7498b5b4e5bb804c1c245c31ca6c3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c431t-50fcad29f400fd19118a5ca5cbd32986906e7498b5b4e5bb804c1c245c31ca6c3 |
| container_end_page | 606 |
| container_issue | 6 |
| container_start_page | 599 |
| container_title | Lupus |
| container_volume | 29 |
| creator | Xia, Yuan-Rui Li, Qing-Ru Wang, Jun-Ping Guo, Heng-Sheng Bao, Yu-Qing Mao, Yan-Mei Wu, Jun Pan, Hai-Feng Ye, Dong-Qing |
| description | Objective
This study aimed to assess systematically the overall diagnostic value of urinary monocyte chemoattractant protein-1 (uMCP-1) in systemic lupus erythematosus (SLE) patients with active lupus nephritis (LN).
Methods
Articles from PubMed, Web of Science, EMBASE and Cochrane Library were retrieved up to 5 November 2019. Study quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 tool, and statistical analyses were performed.
Results
A total of seven original studies with 521 participants were included in this meta-analysis. The summary estimates were: sensitivity 0.89 (95% confidence interval (CI) 0.86–0.93), specificity 0.63 (95% CI 0.55–0.69), positive likelihood ratio 2.16 (95% CI 1.66–2.80), negative likelihood ratio 0.15 (95% CI 0.08–0.30), diagnostic odds ratio 19.40 (95% CI 7.24–51.96) and area under the curve 0.9042.
Conclusion
As a non-invasive biomarker, uMCP-1 has high diagnostic accuracy for active LN. |
| doi_str_mv | 10.1177/0961203320914372 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2383519390</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0961203320914372</sage_id><sourcerecordid>2394057812</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-50fcad29f400fd19118a5ca5cbd32986906e7498b5b4e5bb804c1c245c31ca6c3</originalsourceid><addsrcrecordid>eNp1kc1r3DAQxUVpaLZp7z0VQS-9uJmR5A_1VpJ-QSCX9mzGWnlXwZa2khzYQ__3yGzaQqAgGND83pthHmNvED4gtu0l6AYFSClAo5KteMY2qNq2Kv_iOdus7Wrtn7OXKd0BgETdvGDnUgjoWq037Pe1o50PKTvD72laLA8jX6LzFI98Dj6YY7bc7O0cKOdIJpPP_BBDts5XyJ3ndtVRdn7H897ygrh7l4-r0bQclsS9Peyjyy595MRnm6kiT9MxufSKnY00Jfv6sV6wn18-_7j6Vt3cfv1-9emmMkpirmoYDW2FHhXAuEWN2FFtyhu2Uuiu0dDYVuluqAdl62HoQBk0QtVGoqHGyAv2_uRbFv-12JT72SVjp4m8DUvqhexkjVpqKOi7J-hdWGLZd6W0grrtUBQKTpSJIaVox_4Q3Vxu1iP0azT902iK5O2j8TLMdvtX8CeLAlQnINHO_pv6X8MHqzyXPg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2394057812</pqid></control><display><type>article</type><title>Diagnostic value of urinary monocyte chemoattractant protein-1 in evaluating the activity of lupus nephritis: a meta-analysis</title><source>SAGE</source><creator>Xia, Yuan-Rui ; Li, Qing-Ru ; Wang, Jun-Ping ; Guo, Heng-Sheng ; Bao, Yu-Qing ; Mao, Yan-Mei ; Wu, Jun ; Pan, Hai-Feng ; Ye, Dong-Qing</creator><creatorcontrib>Xia, Yuan-Rui ; Li, Qing-Ru ; Wang, Jun-Ping ; Guo, Heng-Sheng ; Bao, Yu-Qing ; Mao, Yan-Mei ; Wu, Jun ; Pan, Hai-Feng ; Ye, Dong-Qing</creatorcontrib><description>Objective
This study aimed to assess systematically the overall diagnostic value of urinary monocyte chemoattractant protein-1 (uMCP-1) in systemic lupus erythematosus (SLE) patients with active lupus nephritis (LN).
Methods
Articles from PubMed, Web of Science, EMBASE and Cochrane Library were retrieved up to 5 November 2019. Study quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 tool, and statistical analyses were performed.
Results
A total of seven original studies with 521 participants were included in this meta-analysis. The summary estimates were: sensitivity 0.89 (95% confidence interval (CI) 0.86–0.93), specificity 0.63 (95% CI 0.55–0.69), positive likelihood ratio 2.16 (95% CI 1.66–2.80), negative likelihood ratio 0.15 (95% CI 0.08–0.30), diagnostic odds ratio 19.40 (95% CI 7.24–51.96) and area under the curve 0.9042.
Conclusion
As a non-invasive biomarker, uMCP-1 has high diagnostic accuracy for active LN.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203320914372</identifier><identifier>PMID: 32208799</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Lupus ; Lupus nephritis ; Meta-analysis ; Monocyte chemoattractant protein ; Monocyte chemoattractant protein 1 ; Monocytes ; Nephritis ; Quality control ; Statistical analysis ; Systemic lupus erythematosus</subject><ispartof>Lupus, 2020-05, Vol.29 (6), p.599-606</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-50fcad29f400fd19118a5ca5cbd32986906e7498b5b4e5bb804c1c245c31ca6c3</citedby><cites>FETCH-LOGICAL-c431t-50fcad29f400fd19118a5ca5cbd32986906e7498b5b4e5bb804c1c245c31ca6c3</cites><orcidid>0000-0002-4708-3451</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908,79115</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32208799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xia, Yuan-Rui</creatorcontrib><creatorcontrib>Li, Qing-Ru</creatorcontrib><creatorcontrib>Wang, Jun-Ping</creatorcontrib><creatorcontrib>Guo, Heng-Sheng</creatorcontrib><creatorcontrib>Bao, Yu-Qing</creatorcontrib><creatorcontrib>Mao, Yan-Mei</creatorcontrib><creatorcontrib>Wu, Jun</creatorcontrib><creatorcontrib>Pan, Hai-Feng</creatorcontrib><creatorcontrib>Ye, Dong-Qing</creatorcontrib><title>Diagnostic value of urinary monocyte chemoattractant protein-1 in evaluating the activity of lupus nephritis: a meta-analysis</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Objective
This study aimed to assess systematically the overall diagnostic value of urinary monocyte chemoattractant protein-1 (uMCP-1) in systemic lupus erythematosus (SLE) patients with active lupus nephritis (LN).
Methods
Articles from PubMed, Web of Science, EMBASE and Cochrane Library were retrieved up to 5 November 2019. Study quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 tool, and statistical analyses were performed.
Results
A total of seven original studies with 521 participants were included in this meta-analysis. The summary estimates were: sensitivity 0.89 (95% confidence interval (CI) 0.86–0.93), specificity 0.63 (95% CI 0.55–0.69), positive likelihood ratio 2.16 (95% CI 1.66–2.80), negative likelihood ratio 0.15 (95% CI 0.08–0.30), diagnostic odds ratio 19.40 (95% CI 7.24–51.96) and area under the curve 0.9042.
Conclusion
As a non-invasive biomarker, uMCP-1 has high diagnostic accuracy for active LN.</description><subject>Lupus</subject><subject>Lupus nephritis</subject><subject>Meta-analysis</subject><subject>Monocyte chemoattractant protein</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Monocytes</subject><subject>Nephritis</subject><subject>Quality control</subject><subject>Statistical analysis</subject><subject>Systemic lupus erythematosus</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kc1r3DAQxUVpaLZp7z0VQS-9uJmR5A_1VpJ-QSCX9mzGWnlXwZa2khzYQ__3yGzaQqAgGND83pthHmNvED4gtu0l6AYFSClAo5KteMY2qNq2Kv_iOdus7Wrtn7OXKd0BgETdvGDnUgjoWq037Pe1o50PKTvD72laLA8jX6LzFI98Dj6YY7bc7O0cKOdIJpPP_BBDts5XyJ3ndtVRdn7H897ygrh7l4-r0bQclsS9Peyjyy595MRnm6kiT9MxufSKnY00Jfv6sV6wn18-_7j6Vt3cfv1-9emmMkpirmoYDW2FHhXAuEWN2FFtyhu2Uuiu0dDYVuluqAdl62HoQBk0QtVGoqHGyAv2_uRbFv-12JT72SVjp4m8DUvqhexkjVpqKOi7J-hdWGLZd6W0grrtUBQKTpSJIaVox_4Q3Vxu1iP0azT902iK5O2j8TLMdvtX8CeLAlQnINHO_pv6X8MHqzyXPg</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Xia, Yuan-Rui</creator><creator>Li, Qing-Ru</creator><creator>Wang, Jun-Ping</creator><creator>Guo, Heng-Sheng</creator><creator>Bao, Yu-Qing</creator><creator>Mao, Yan-Mei</creator><creator>Wu, Jun</creator><creator>Pan, Hai-Feng</creator><creator>Ye, Dong-Qing</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4708-3451</orcidid></search><sort><creationdate>20200501</creationdate><title>Diagnostic value of urinary monocyte chemoattractant protein-1 in evaluating the activity of lupus nephritis: a meta-analysis</title><author>Xia, Yuan-Rui ; Li, Qing-Ru ; Wang, Jun-Ping ; Guo, Heng-Sheng ; Bao, Yu-Qing ; Mao, Yan-Mei ; Wu, Jun ; Pan, Hai-Feng ; Ye, Dong-Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-50fcad29f400fd19118a5ca5cbd32986906e7498b5b4e5bb804c1c245c31ca6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Lupus</topic><topic>Lupus nephritis</topic><topic>Meta-analysis</topic><topic>Monocyte chemoattractant protein</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Monocytes</topic><topic>Nephritis</topic><topic>Quality control</topic><topic>Statistical analysis</topic><topic>Systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xia, Yuan-Rui</creatorcontrib><creatorcontrib>Li, Qing-Ru</creatorcontrib><creatorcontrib>Wang, Jun-Ping</creatorcontrib><creatorcontrib>Guo, Heng-Sheng</creatorcontrib><creatorcontrib>Bao, Yu-Qing</creatorcontrib><creatorcontrib>Mao, Yan-Mei</creatorcontrib><creatorcontrib>Wu, Jun</creatorcontrib><creatorcontrib>Pan, Hai-Feng</creatorcontrib><creatorcontrib>Ye, Dong-Qing</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xia, Yuan-Rui</au><au>Li, Qing-Ru</au><au>Wang, Jun-Ping</au><au>Guo, Heng-Sheng</au><au>Bao, Yu-Qing</au><au>Mao, Yan-Mei</au><au>Wu, Jun</au><au>Pan, Hai-Feng</au><au>Ye, Dong-Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic value of urinary monocyte chemoattractant protein-1 in evaluating the activity of lupus nephritis: a meta-analysis</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>29</volume><issue>6</issue><spage>599</spage><epage>606</epage><pages>599-606</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Objective
This study aimed to assess systematically the overall diagnostic value of urinary monocyte chemoattractant protein-1 (uMCP-1) in systemic lupus erythematosus (SLE) patients with active lupus nephritis (LN).
Methods
Articles from PubMed, Web of Science, EMBASE and Cochrane Library were retrieved up to 5 November 2019. Study quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 tool, and statistical analyses were performed.
Results
A total of seven original studies with 521 participants were included in this meta-analysis. The summary estimates were: sensitivity 0.89 (95% confidence interval (CI) 0.86–0.93), specificity 0.63 (95% CI 0.55–0.69), positive likelihood ratio 2.16 (95% CI 1.66–2.80), negative likelihood ratio 0.15 (95% CI 0.08–0.30), diagnostic odds ratio 19.40 (95% CI 7.24–51.96) and area under the curve 0.9042.
Conclusion
As a non-invasive biomarker, uMCP-1 has high diagnostic accuracy for active LN.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>32208799</pmid><doi>10.1177/0961203320914372</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4708-3451</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0961-2033 |
| ispartof | Lupus, 2020-05, Vol.29 (6), p.599-606 |
| issn | 0961-2033 1477-0962 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2383519390 |
| source | SAGE |
| subjects | Lupus Lupus nephritis Meta-analysis Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Nephritis Quality control Statistical analysis Systemic lupus erythematosus |
| title | Diagnostic value of urinary monocyte chemoattractant protein-1 in evaluating the activity of lupus nephritis: a meta-analysis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T19%3A41%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diagnostic%20value%20of%20urinary%20monocyte%20chemoattractant%20protein-1%20in%20evaluating%20the%20activity%20of%20lupus%20nephritis:%20a%20meta-analysis&rft.jtitle=Lupus&rft.au=Xia,%20Yuan-Rui&rft.date=2020-05-01&rft.volume=29&rft.issue=6&rft.spage=599&rft.epage=606&rft.pages=599-606&rft.issn=0961-2033&rft.eissn=1477-0962&rft_id=info:doi/10.1177/0961203320914372&rft_dat=%3Cproquest_cross%3E2394057812%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c431t-50fcad29f400fd19118a5ca5cbd32986906e7498b5b4e5bb804c1c245c31ca6c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2394057812&rft_id=info:pmid/32208799&rft_sage_id=10.1177_0961203320914372&rfr_iscdi=true |