Urinary 8-oxo-7,8-dihydroguanosine as a potential biomarker of frailty for elderly patients with cardiovascular disease

The diagnosis of frailty is usually subjective, which calls for objective biomarkers in clinical medicine. 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGsn) and 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) in urine are two aging biomarkers that have not been explored deeply in cases of frailty. A total of 5...

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Published in:Free radical biology & medicine 2020-05, Vol.152, p.248-254
Main Authors: Liang, Yao-Dan, Liu, Qian, Du, Ming-Hui, Liu, Zhen, Yao, Si-Min, Zheng, Pei-Pei, Wan, Yu-Hao, Sun, Ning, Li, Ying-Ying, Liu, Jun-Peng, Luo, Yao, Cai, Jian-Ping, Yang, Jie-Fu, Wang, Hua
Format: Article
Language:English
Subjects:
8-OxodGsn
8-OxoGsn
Biomarker
Frailty
Oxidative stress
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Summary:The diagnosis of frailty is usually subjective, which calls for objective biomarkers in clinical medicine. 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGsn) and 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) in urine are two aging biomarkers that have not been explored deeply in cases of frailty. A total of 508 elderly patients with cardiovascular disease (mean age 75.0 ± 6.5 years, 50.8% males) were enrolled consecutively. Frailty was assessed by the Fried phenotype (robust: 0 score; pre-frail: 1–2 scores; frail: 3–5 scores). The concentrations of 8-oxoGsn and 8-oxodGsn in urine were measured by improved ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). Urinary creatinine (Cre) was tested to correct the 8-oxoGsn and 8-oxodGsn levels. According to the Fried phenotype score, the proportions of robust, pre-frail, and frail subjects were 20.5% (104/508), 53.9% (274/508), and 25.6% (130/508), respectively. The urinary 8-oxoGsn/Cre (P 
ISSN:0891-5849
1873-4596
DOI:10.1016/j.freeradbiomed.2020.03.011