Factors associated with severity of adverse events following yellow fever vaccination during the biggest outbreak of the disease recorded in Brazil, 2016-2017

to analyze characteristics, incidence and factors associated with serious adverse events (SAEs) following yellow fever vaccination during an outbreak of the disease in Brazil (2016-2017). this was a case-control study using data from the National Immunization Program Information System (SI-PNI); SAE...

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Published in:Epidemiologia e serviços de saúde 2020, Vol.29 (1), p.e2018331-e2018331
Main Authors: Lucena, Adriana Regina Farias Pontes, Souza, Líbia Roberta de Oliveira, Percio, Jadher, Carvalho, Sandra Maria Deotti, Romano, Alessandro Pecego Martins, Domingues, Carla Magda Allan Santos
Format: Article
Language:eng ; por
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Summary:to analyze characteristics, incidence and factors associated with serious adverse events (SAEs) following yellow fever vaccination during an outbreak of the disease in Brazil (2016-2017). this was a case-control study using data from the National Immunization Program Information System (SI-PNI); SAE were considered to be cases, and non-serious adverse events (NSAE) were considered to be controls. we analyzed 135 SAE cases and 1,058 controls; of the 135 SAE, 79 (58.5%) were males and median age was 28 years [09-49]; incidence in January 2017 reached 1.3 case per 100,000 vaccine doses administered; there was statistical association with males (Odds Ratio [OR]=1.73 - 95%CI 1.20;2.48), primary vaccination (OR=1.65 - 95%CI 1.01;2.71), and being 60 years of age or older taking as reference those aged under 5 (OR=4.4; p-value
ISSN:2237-9622
DOI:10.5123/S1679-49742020000100017