Role of Aquaporins in Spermatogenesis and Testicular Steroidogenesis

The transport of water and several other small molecules across cell membranes is vital in many of the processes underlying reproduction. Fluid transport in cells and tissues inclusive of male reproductive organs are regulated by disparate isoforms of aquaporins (AQPs) in living organisms. Alteratio...

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Bibliographic Details
Published in:The Journal of membrane biology 2020-04, Vol.253 (2), p.109-114
Main Authors: Kannan, Arun, Panneerselvam, Antojenifer, Mariajoseph-Antony, Lezy Flora, Loganathan, Chithra, Prahalathan, Chidambaram
Format: Article
Language:English
Subjects:
Animals
Aquaporins
Aquaporins - genetics
Aquaporins - metabolism
Biochemistry
Biomedical and Life Sciences
Cell membranes
Fertility
Genitalia, Male - physiology
Human Physiology
Humans
Infertility
Isoforms
Life Sciences
Male
Molecular modelling
Organs
Reproductive organs
Reproductive system
Spermatogenesis
Steroidogenesis
Steroids - biosynthesis
Testis - physiology
Topical Review
Transport
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Summary:The transport of water and several other small molecules across cell membranes is vital in many of the processes underlying reproduction. Fluid transport in cells and tissues inclusive of male reproductive organs are regulated by disparate isoforms of aquaporins (AQPs) in living organisms. Alteration in the expression, function and/or regulation of AQPs leads to some forms of male subfertility and infertility. The emerging role of AQPs in male and female reproductive function has been revealed in recent times. However, the role of AQPs with reference to male reproductive system needs to be explored in greater detail. This review emphasizes the distribution of AQPs and their physiological and pathophysiological role in spermatogenesis and steroidogenesis; and understanding the molecular mechanisms behind AQPs mediated regulation of spermatogenesis and steroidogenesis will help us in developing treatment strategies towards improved reproductive health.
ISSN:0022-2631
1432-1424
DOI:10.1007/s00232-020-00114-5