Therapeutic Application of Small Extracellular Vesicles (sEVs): Pharmaceutical and Pharmacokinetic Challenges

Small extracellular vesicles (sEVs), including exosomes as typical example, are cell-derived vesicles comprising lipid bilayer with a diameter approximately 100 nm. sEVs are endogenous delivery vehicles that deliver their contents such as nucleic acids and proteins to recipient cells. Because of the...

Full description

Saved in:
Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2020/04/01, Vol.43(4), pp.576-583
Main Authors: Takakura, Yoshinobu, Matsumoto, Akihiro, Takahashi, Yuki
Format: Article
Language:English
Subjects:
Drug delivery
exosome
Exosomes
Extracellular vesicles
Lipid bilayers
pharmaceutical challenge
pharmacokinetic challenge
Pharmacokinetics
small extracellular vesicle (sEV)
therapeutic application
Therapeutic applications
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Small extracellular vesicles (sEVs), including exosomes as typical example, are cell-derived vesicles comprising lipid bilayer with a diameter approximately 100 nm. sEVs are endogenous delivery vehicles that deliver their contents such as nucleic acids and proteins to recipient cells. Because of their potential nature as endogenous delivery vehicles, therapeutic applications of sEVs as delivery systems of various drugs are expected. To develop sEV-based therapeutics, a variety of challenges should be overcome. In this review, we summarize the current status and future perspectives of therapeutic applications of sEVs. Several pharmaceutical and pharmacokinetic challenges will be discussed.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b19-00831