Characterization and effect of nanocomplexed fluoride solutions on the inhibition of enamel demineralization created by a multispecies cariogenic biofilm model

Objectives The aim of this study was to assess the in vitro caries preventive effect of nanocomplexed solutions of hydroxypropyl-β-cyclodextrin and γ-cyclodextrin associated with titanium tetrafluoride (TiF 4 ) after different complexation times (12 or 72 h). Materials and methods Enamel blocks were...

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Bibliographic Details
Published in:Clinical oral investigations 2020-11, Vol.24 (11), p.3947-3959
Main Authors: Vieira, Thiago I., Alexandria, Adílis K., Menezes, Jaqueline C. V., do Amaral, Lilian H., dos Santos, Thaís M. P., Neves, Aline de A., Lopes, Ricardo T., Cabral, Lúcio M., Valença, Ana M. G., Maia, Lucianne C.
Format: Article
Language:English
Subjects:
Biofilms
Cariostatic Agents
Dental Enamel
Dentistry
Fluorides
Medicine
Minerals
Original Article
Sodium Fluoride
Titanium
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Summary:Objectives The aim of this study was to assess the in vitro caries preventive effect of nanocomplexed solutions of hydroxypropyl-β-cyclodextrin and γ-cyclodextrin associated with titanium tetrafluoride (TiF 4 ) after different complexation times (12 or 72 h). Materials and methods Enamel blocks were randomly distributed in 9 groups ( n  = 11): negative control, hydroxypropyl-β-cyclodextrin, γ-cyclodextrin, TiF 4 , hydroxypropyl-β-cyclodextrin:TiF 4 12 h, hydroxypropyl-β-cyclodextrin:TiF 4 72 h, γ-cyclodextrin:TiF 4 12 h, γ-cyclodextrin:TiF 4 72 h, and NaF (positive control). The solutions were applied for 1 min and the blocks were exposed to a biofilm model. Nanocompounds were characterized by differential scanning calorimetry and X-ray powder diffraction. The percentage of surface microhardness loss (%SML), mineral density changes (Δ Z ), lesion depth, surface morphology (scanning electron microscopy—SEM), and chemical characterization (energy-dispersive spectroscopy—EDS) were assessed. Results No oxidation was observed, and the formation of the nanocomplexes was evidenced by changes in the melting point compared to pure cyclodextrins and the loss of crystallinity of the materials. Hydroxypropyl-β-cyclodextrin:TiF 4 72 h resulted in lower %SML than negative control, hydroxypropyl-β-cyclodextrin, γ-cyclodextrin, and TiF 4 ( p  
ISSN:1432-6981
1436-3771
DOI:10.1007/s00784-020-03261-0