Injectable Enzyme‐Based Hydrogel Matrix with Precisely Oxidative Stress Defense for Promoting Dermal Repair of Burn Wound

• Published in: Macromolecular bioscience 2020-06, Vol.20 (6), p.e2000036-n/a
• Main Authors: Zhang, Dongmei, Wang, Bulei, Sun, Yajuan, Wang, Changhao, Mukherjee, Somnath, Yang, Cheng, Chen, Yashao
• Format: Article
• Language: English
• Subjects: Antioxidants; Apoptosis; Biomaterials; Biomedical materials; burn wound healing; Catechol; Collagen; Coupling (molecular); Extracellular matrix; Fibrosis; Hydrogels; Inflammation; Inflammatory response; injectable hydrogel; Iron; Lipid peroxidation; Lipids; Oxidative stress; oxidative stress defense; Peroxidation; Reactive oxygen species; Regeneration; Repair; Scavenging; Skin; skin regeneration; Superoxide; Tissues; Vitamin E; Wound healing
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.202000036

Burn wound healing remains a challenging health problem worldwide due to the lack of efficient and precise therapy. Inherent oxidative stress following burn injury is importantly responsible for prolonged inflammation, fibrotic scar, and multiple organ failure. Herein, a bioinspired antioxidative defense system coupling with in situ forming hydrogel, namely, multiresponsive injectable catechol‐Fe3+ coordination hydrogel (MICH) matrix, is engineered to promote burn‐wound dermal repair by inhibiting tissue oxidative stress. This MICH matrix serves as the special traits of “Fe‐superoxide dismutases,” small molecular antioxidant (vitamin E), and extracellular matrix (ECM) in alleviating cellular oxidative damage, which demonstrates precise scavenging on reactive oxygen species (ROS) of different cellular locations, blocking lipid peroxidation and cell apoptosis. In in vivo burn‐wound treatment, this MICH promptly integrates with injured surrounding tissue to provide hydration microenvironment and physicochemical ECM for burn wounds. Importantly, the MICH matrix suppresses tissue ROS production, reducing the inflammatory response, prompting re‐epithelization and neoangiogenesis during wound healing. Meanwhile, the remodeling skin treated with MICH matrix demonstrates low collagen deposition and normal dermal collagen architecture. Overall, the MICH prevents burn wound progression and enhances skin regeneration, which might be a promising biomaterial for burn‐wound care and other disease therapy induced by oxidative stress. Bioinspired antioxidative defense system coupling with in situ forming multiresponsive injectable hydrogel, multiresponsive injectable catechol‐Fe3+ coordination hydrogel matrix, is engineered to precisely eliminate reactive oxygen species from different cellular locations. This matrix alleviates burn‐mediated oxidative damage and provides an ideal microenvironment for wound healing, thus promoting dermal regeneration. This strategy may be a promising biomedical material for dermal repair of burn‐wound and other disease therapy.