Ozone therapy in veterinary medicine: A review

Ozone (O3) is a triatomic form of oxygen. As O3 rapidly dissociates into water and releases a reactive form of oxygen that may oxidize cells, the gas mixture of O3/O2 is used in medicine. ATP is widely available for cellular activity. O3 can be administered via the systemic and local routes. Althoug...

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Bibliographic Details
Published in:Research in veterinary science 2020-06, Vol.130, p.240-246
Main Authors: Sciorsci, R.L., Lillo, E., Occhiogrosso, L., Rizzo, A.
Format: Article
Language:English
Subjects:
Antimicrobial
Antimicrobial agents
Antioxidants
Beta rays
Disease
Enzymes
Fatty acids
Free radicals
Fungi
Gas mixtures
Immune response
Immune system
Lipids
Mammals
Medicine
Oxidants
Oxidative mechanism
Oxidative stress
Oxidizing agents
Oxygen
Ozone
Pollutants
Proteins
Protozoa
Signal transduction
Stratosphere
Tumor necrosis factor-TNF
Veterinary medicine
Viruses
Yeasts
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Summary:Ozone (O3) is a triatomic form of oxygen. As O3 rapidly dissociates into water and releases a reactive form of oxygen that may oxidize cells, the gas mixture of O3/O2 is used in medicine. ATP is widely available for cellular activity. O3 can be administered via the systemic and local routes. Although O3 is known as one of the most powerful oxidants, it also promotes antioxidant enzymes. Additionally, it stimulates some of the cells of the immune system and inactivates pathogens, including bacteria, fungi, yeasts, protozoa, and viruses. Owing to these activities, O3 is used to improve several diseases, both in human and in veterinary medicine. Considering the wide scope of O3 application, the aim of this review was to reiterate the mechanisms of action of O3 and its utilization in different mammalian species (bovine, ovine-caprine, equine, canine, porcine). •Ozone (O3) is a triatomic form of oxygen normally present in athmosphere.•O3 is widely used in human and veterinary medicine through several pharmaceutical forms.•O3 has antioxidant, anti-inflammatory, immuno-stimulant and microbicidal effect.•This review focuses on O3 mechanisms of action and on its main application in Veterinary Medicine.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2020.03.026