Upfront Surgery for Small Intestinal Non-Hodgkin's Lymphoma

The clinical significance of surgery for secondary small intestinal non-Hodgkin's lymphomas (NHL) remains unknown. This study aimed to investigate the efficacy of resection for both primary and secondary small intestinal NHL. Twenty patients with small intestinal lymphoma who underwent surgical...

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Bibliographic Details
Published in:Anticancer research 2020-04, Vol.40 (4), p.2373-2377
Main Authors: Iida, Tetsuhiro, Nozawa, Hiroaki, Sonoda, Hirofumi, Toyama, Kazuhiro, Kawai, Kazushige, Hata, Keisuke, Tanaka, Toshiaki, Nishikawa, Takeshi, Sasaki, Kazuhito, Shuno, Yasutaka, Kaneko, Manabu, Murono, Koji, Emoto, Shigenobu, Ishii, Hiroaki, Kurokawa, Mineo, Ishihara, Soichiro
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Chemotherapy
Combined Modality Therapy
Complications
Disease-Free Survival
Embolism
Female
Health risk assessment
Humans
Intestine
Intestine, Small - drug effects
Intestine, Small - pathology
Intestine, Small - surgery
Lymphoma
Lymphoma, Non-Hodgkin - drug therapy
Lymphoma, Non-Hodgkin - surgery
Male
Middle Aged
Non-Hodgkin's lymphoma
Patients
Retrospective Studies
Surgery
Surgical outcomes
Thromboembolism
Thrombosis
Treatment Outcome
Young Adult
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Summary:The clinical significance of surgery for secondary small intestinal non-Hodgkin's lymphomas (NHL) remains unknown. This study aimed to investigate the efficacy of resection for both primary and secondary small intestinal NHL. Twenty patients with small intestinal lymphoma who underwent surgical resection at our Institute between 2009 and 2017 were retrospectively evaluated. The clinicopathological and surgery-related factors were reviewed. We also analyzed their surgical outcomes such as postoperative complications, perforation rate, and overall survival (OS). In total, 13 (65%) and 7 (35%) patients had primary and secondary lymphomas, respectively. A total of 70% of patients were diagnosed with aggressive-type lymphomas. A total of 15 (75%) patients had Lugano system stage IV. Only one (5%) patient experienced postoperative grade II deep vein thrombosis and pulmonary embolism. The 3-year OS rate after surgery was 59.6%. Surgical resection prior to chemotherapy is a feasible and safe therapeutic strategy for small intestinal NHL.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.14206