Synthesis and Synthetic Application of Chloro- and Bromofuroxans

Furoxans are potentially useful heteroaromatic units in pharmaceuticals and agrichemicals. However, the applications for furoxan-based compounds have been hampered due to the underdevelopment of their synthetic methods. Herein, we report a new synthetic approach for the synthesis of chloro- and brom...

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Bibliographic Details
Published in:Journal of organic chemistry 2020-05, Vol.85 (9), p.5959-5972
Main Authors: Matsubara, Ryosuke, Ando, Akihiro, Hasebe, Hayu, Kim, Hojin, Tsuneda, Takao, Hayashi, Masahiko
Format: Article
Language:English
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Summary:Furoxans are potentially useful heteroaromatic units in pharmaceuticals and agrichemicals. However, the applications for furoxan-based compounds have been hampered due to the underdevelopment of their synthetic methods. Herein, we report a new synthetic approach for the synthesis of chloro- and bromofuroxans. The starting materials were dichloro- and dibromofuroxans, and the substituents were directly introduced to the furoxan ring in a modular fashion. The synthesized monohalofuroxans served as substrates for the installation of a second substituent to prepare further functionalized furoxans.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.0c00326