Peptide KE in Human Proteome

Peptide KE exhibits immunoprotective, geroprotective, and oncostatic activities and stimulates functional activity of fibroblasts. The KE motif is present in amino acid sequences of some cytokines and peptide hormones functionally similar to KE peptide. However, the relationship between the presence...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020-03, Vol.168 (5), p.631-633
Main Authors: Terekhov, A. Yu, Kormilets, D. Yu, Linkova, N. S., Kuznik, B. I., Mar’yanovich, A. T., Khavinson, V. Kh
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cytokines
Cytokines - chemistry
Databases, Protein
Fibroblasts
Gene expression
Genes
Glutamic Acid - chemistry
Hormones - chemistry
Humans
Internal Medicine
Laboratory Medicine
Lysine - chemistry
Nuclear Proteins - chemistry
Pathology
Peptide hormones
Peptides
Peptides - analysis
Peptides - chemistry
Protein binding
Proteins
Proteolysis
Proteome - analysis
Proteome - chemistry
Proteomes
Sequence Analysis, Protein
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Summary:Peptide KE exhibits immunoprotective, geroprotective, and oncostatic activities and stimulates functional activity of fibroblasts. The KE motif is present in amino acid sequences of some cytokines and peptide hormones functionally similar to KE peptide. However, the relationship between the presence of KE motif and protein functions on the scale of known human proteome has not yet received sufficient attention. The incidence of bioregulatory peptide KE in proteins of various functional groups constituting human proteome is studied. The study is carried out with the use of the available data on the human proteome (UniProt portal) comprising 20,417 proteins. The levels of KE motifs were maximum in cytoplasmic and nuclear proteins, while the presence of KE in the membrane and all other proteins was the minimum. KE peptide molecules released from nuclear proteins during limited proteolysis can bind to DNA and regulate gene expression.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04767-z