Targeting estrogen receptors in colorectal cancer

Hormones have become a useful therapeutic aspect of clinical endocrinology but how to use them to optimize the health benefits and avoid adverse effects is a major challenge. Estrogen is an indispensable hormone for proper biological functioning but is also implicated with the pathology of both the...

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Bibliographic Details
Published in:Molecular biology reports 2020-05, Vol.47 (5), p.4087-4091
Main Authors: Maingi, Joyce Wanjiru, Tang, Shu, Liu, Sirui, Ngenya, Watson, Bao, Endong
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Colon - metabolism
Colonic Neoplasms - genetics
Colonic Neoplasms - metabolism
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - therapy
Endocrine therapy
Endocrinology
Epithelium
Estrogen Receptor alpha - genetics
Estrogen Receptor alpha - metabolism
Estrogen Receptor beta - genetics
Estrogen Receptor beta - metabolism
Estrogen Receptor beta - therapeutic use
Estrogen receptors
Estrogens
Estrogens - metabolism
Estrogens - pharmacology
Female
Gene Expression Regulation, Neoplastic - genetics
Histology
Humans
Intestinal Mucosa - metabolism
Life Sciences
Mini Review Article
Morphology
Phytoestrogens - metabolism
Phytoestrogens - pharmacology
Receptors, Estrogen - genetics
Receptors, Estrogen - metabolism
Receptors, Estrogen - therapeutic use
Signal Transduction - genetics
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Summary:Hormones have become a useful therapeutic aspect of clinical endocrinology but how to use them to optimize the health benefits and avoid adverse effects is a major challenge. Estrogen is an indispensable hormone for proper biological functioning but is also implicated with the pathology of both the reproductive and non-reproductive tissues. Abnormal estrogen receptor signaling may increase the risk of development of a variety of diseases including colorectal cancer (CRC). Estrogen receptor beta (ERβ) is the predominant subtype in the colonic epithelium and confers the anti-tumor effect through various mechanisms. Many investigators have embarked on the search for the biological mechanisms by which estrogen and estrogen-like compounds may influence the pathogenesis of CRC. This review explores the recent findings on the therapeutic role of ERβ in the colonic epithelium as a prospective candidate for targeted endocrine therapy in CRC.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-020-05414-6