Excretion characteristics and tissue accumulation of tetrabromobisphenol-A in male rats after sub-chronic inhalation exposure

Tetrabromobisphenol-A (TBBPA) is an emerging organic pollutant and a commonly used brominated flame retardant that has received much attention owing to its toxicity. Although TBBPA is ubiquitously detected in atmospheric particulate matter and dust, few studies have investigated the sub-chronic inha...

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Published in:Environmental pollution (1987) 2020-08, Vol.263 (Pt B), p.114440-114440, Article 114440
Main Authors: Yu, Yun jiang, Chen, Xi chao, Wang, Zheng dong, Liu, Li ting, Ge, Qing zhi, Wang, Qiong, Zhang, Yan ping, Yu, Zi ling, Ma, Rui xue
Format: Article
Language:English
Subjects:
Excretion
Rat
Sub-chronic inhalation exposure
Tetrabromobisphenol-A
Tissues
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Summary:Tetrabromobisphenol-A (TBBPA) is an emerging organic pollutant and a commonly used brominated flame retardant that has received much attention owing to its toxicity. Although TBBPA is ubiquitously detected in atmospheric particulate matter and dust, few studies have investigated the sub-chronic inhalation exposure to TBBPA. To further understand the excretion characteristics and tissue accumulation of TBBPA after inhalation exposure, we used the rat model to conduct a sub-chronic inhalation exposure study. Male rats were administered with different doses of aerosol TBBPA (12.9, 54.6, 121.6, and 455.0 mg/m3). TBBPA was found in the excretion (feces and urine) and all the target tissues (lung, liver, heart, thymus gland, spleen, testicles, muscles, kidneys, brain and serum). Feces were the main route of excretion, which contributed 19.18% to 72.54% (urine
ISSN:0269-7491
1873-6424
DOI:10.1016/j.envpol.2020.114440