How long is long enough? Good neurologic outcome in out-of-hospital cardiac arrest survivors despite prolonged resuscitation: a retrospective cohort study

Background Despite all efforts, mortality of out of hospital cardiac arrest (OHCA) remains high. Patients with OHCA due to a primary shockable rhythm typically have a better prognosis. However, outcome worsens if return of spontaneous circulation (ROSC) cannot be achieved quickly. There is insuffici...

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Published in:Clinical research in cardiology 2020-11, Vol.109 (11), p.1402-1410
Main Authors: Braumann, Simon, Nettersheim, Felix Sebastian, Hohmann, Christopher, Tichelbäcker, Tobias, Hellmich, Martin, Sabashnikov, Anton, Djordjevic, Ilija, Adler, Joana, Nies, Richard Julius, Mehrkens, Dennis, Lee, Samuel, Stangl, Robert, Reuter, Hannes, Baldus, Stephan, Adler, Christoph
Format: Article
Language:English
Subjects:
Cardiac arrest
Cardiology
Cohort analysis
Heart
Lactic acid
Medicine
Medicine & Public Health
Mortality
Original Paper
Resuscitation
Rhythm
Survival
Urban areas
Urban environments
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Summary:Background Despite all efforts, mortality of out of hospital cardiac arrest (OHCA) remains high. Patients with OHCA due to a primary shockable rhythm typically have a better prognosis. However, outcome worsens if return of spontaneous circulation (ROSC) cannot be achieved quickly. There is insufficient evidence for maximum duration of resuscitation in these patients and it is unclear, which patients profit from transport under ongoing CPR. Objective Investigate predictors for favourable neurologic outcome in OHCA patients with presumed cardiac cause due to refractory shockable rhythm (rSR). Methods Retrospective analysis of OHCA patients that presented to a tertiary hospital due to a rSR. Results One hundred seventy-five OHCA patients with presumed cardiac cause due to rSR were included. Overall hospital mortality was 50% and 83% of initial survivors were discharged with a good neurologic outcome [cerebral performance category (CPC) 1–2]. In patients with a time from cardiac arrest to ROSC of > 45 min, 18% survived to CPC 1–2. Independent predictors for good neurologic outcome were age, lower no-flow time and lower serum lactate levels at hospital arrival. Conclusion In an urban setting, a significant proportion of OHCA patients with rSR can survive to a good neurologic outcome, despite very long time to ROSC. Graphic abstract
ISSN:1861-0684
1861-0692
DOI:10.1007/s00392-020-01640-x