Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging

Morphometric analysis of structural and functional changes in the human mesenteric lymph nodes during aging revealed the development of fibrous connective tissue, fragmentation of the lymphoid parenchyma, the absence of follicles with germinal centers, and a decrease in the level of lymphocyte proli...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020-03, Vol.168 (5), p.694-698
Main Authors: Erofeeva, L. M., Mnikhovich, M. V.
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Aging
Aging - pathology
Aging - physiology
Analysis
Autopsy
Biogerontology
Biomedical and Life Sciences
Biomedicine
CD4 antigen
Cell Biology
Cell proliferation
Connective tissues
Female
Follicles
Germinal centers
Humans
Humoral immunity
Internal Medicine
Laboratory Medicine
Leukocytes (eosinophilic)
Leukocytes (granulocytic)
Lymph nodes
Lymph Nodes - pathology
Lymphatic system
Lymphocytes T
Male
Mesentery
Middle Aged
Morphometry
Parenchyma
Pathology
Plasma cells
Structure-function relationships
T cells
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Summary:Morphometric analysis of structural and functional changes in the human mesenteric lymph nodes during aging revealed the development of fibrous connective tissue, fragmentation of the lymphoid parenchyma, the absence of follicles with germinal centers, and a decrease in the level of lymphocyte proliferation, which was confirmed by the absence of Ki-67 + cells. The paracortical zone lacked CD4 + T helpers that regulate both cellular and humoral immunity. High content of plasma cells and eosinophilic granulocytes in the medullary cords and sinuses reflects the development of autoimmune processes associated with a decrease in the number of regulatory T lymphocytes. The development of fibrous connective tissue in the sinus system complicates lymph flow through the lymph node and impairs lymph filtration.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04782-0