Predictive and patient-monitoring biomarkers: precision in the management of colorectal cancer

Considering the similar figures in 2002 and 2009, limited progress has been noted in early diagnosis and death reduction (4). [...]innovated research is rationally focusing on the development of more effective early diagnosis and therapeutic modalities. Clinical management of CRC Despite the standar...

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Published in:Biomarkers in medicine 2020-04, Vol.14 (5), p.335-339
Main Authors: Pappas-Gogos, Georgios, Baltagiannis, Evangelos G, Kyrochristos, Ioannis D, Ziogas, Demosthenes E, Goussia, Anna, Mitsis, Michail, Roukos, Dimitrios H
Format: Article
Language:English
Subjects:
biomarker development
Biomarkers
Biopsy
Cancer therapies
Chemotherapy
Clinical trials
Colorectal cancer
Colorectal carcinoma
Decision making
Deoxyribonucleic acid
Diagnosis
DNA
Genes
Genomes
Medical prognosis
Metastases
Metastasis
Mutation
next-generation sequencing
Patients
Standardization
Studies
tumor heterogeneity
Tumors
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Summary:Considering the similar figures in 2002 and 2009, limited progress has been noted in early diagnosis and death reduction (4). [...]innovated research is rationally focusing on the development of more effective early diagnosis and therapeutic modalities. Clinical management of CRC Despite the standardization of colonoscopic screening, many patients are diagnosed with advanced or metastatic disease. [...]primary prevention, early diagnosis and effective treatment in advanced CRC remain unresolved problems (4). [...]the need to shift from colonoscopic to noninvasive screening is apparent. Considering the dynamic evolution of genomic clones according to Darwinian theory (15), single biopsies are inappropriate to identify the dynamic emergence of intratumor heterogeneity (ITH), which represents as a late event. [...]several studies are focusing on the development of robust predictive biomarkers.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2020-0025