Biodegradable polyester unimolecular systems as emerging materials for therapeutic applications

Unimolecular micelles, as a class of single-molecular micelles, are structurally stable regardless of their concentrations or alterations of the outer environment such as pH, temperature, ion strength etc. in comparison with conventional polymeric micelles. Polyester unimolecular micelles are extens...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2018-09, Vol.6 (35), p.5488-5498
Main Authors: Liu, Xuan, Fan, Xiaoshan, Jiang, Lu, Loh, Xian Jun, Wu, Yun-Long, Li, Zibiao
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradability
Biodegradation
Biomedical materials
Control stability
Cyclodextrin
Cyclodextrins
Drug delivery
Drug delivery systems
Micelles
Polyesters
Polyhedral oligomeric silsesquioxane
Polymers
Precision medicine
Structural stability
Therapeutic applications
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Summary:Unimolecular micelles, as a class of single-molecular micelles, are structurally stable regardless of their concentrations or alterations of the outer environment such as pH, temperature, ion strength etc. in comparison with conventional polymeric micelles. Polyester unimolecular micelles are extensively applied in bio-medical fields because of their stability, biocompatibility, biodegradability, structural-controllabilty etc. In this review, the most recent developments in polyester unimolecular micelle designs in terms of Boltorn polymer H40 core, cyclodextrin, dendrimer or dendrimer-like polymer, or polyhedral oligomeric silsesquioxane (POSS) based polyester unimolecular micelles are presented. The significance and application in biomedical fields including drug delivery, bio-imaging and theranostics are also classified in this review. Finally, the remaining challenges and future perspectives for further development of unimolecular micelles as therapeutic materials are also discussed. Biodegradable polyester unimolecular systems are the future emerging materials for therapeutic applications.
ISSN:2050-750X
2050-7518
DOI:10.1039/c8tb01883a