Targeted and NIR light-controlled delivery of nitric oxide combined with a platinum(iv) prodrug for enhanced anticancer therapy

This study reports a strategy of combining a Pt(iv) prodrug and a ruthenium nitrosyl (Ru-NO) donor into a single nanoplatform {N-GQDs@Ru-NO-Pt@FA} in which the platinum(iv) prodrug is conjugated onto a photoactivatable NO donor (Ru-NO) through a covalent bond and the nitric oxide-releasing platinum...

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Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2019-03, Vol.7 (11), p.1867-1874
Main Authors: Shi, Shu-Wen, Li, Yan-Hui, Zhang, Qian-Ling, Yang, Shi-Ping, Liu, Jin-Gang
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
Cobalt
Covalent bonds
Folic acid
Graphene
Infrared radiation
Irradiation
Light
Light irradiation
Nitric oxide
Platinum
Quantum dots
Radiation
Ruthenium
Therapy
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Summary:This study reports a strategy of combining a Pt(iv) prodrug and a ruthenium nitrosyl (Ru-NO) donor into a single nanoplatform {N-GQDs@Ru-NO-Pt@FA} in which the platinum(iv) prodrug is conjugated onto a photoactivatable NO donor (Ru-NO) through a covalent bond and the nitric oxide-releasing platinum prodrug and folate groups are decorated on N-doped graphene quantum dots (N-GQDs). After cellular uptake of the nanoplatform, the platinum(iv) prodrug was reduced to an active anti-cancer Pt(ii) species inside the cancerous cells, and simultaneously, near-infrared (NIR) light illumination induced the release of NO, accompanied by a prominent photothermal effect. This nanoplatform is capable of targeting intracellular co-delivery of Pt(ii) and NO under 808 nm NIR light irradiation, accompanied by photothermal therapy, thereby leading to a significant synergistic therapeutic effect.
ISSN:2050-750X
2050-7518
DOI:10.1039/c8tb02743a