Targeted and NIR light-controlled delivery of nitric oxide combined with a platinum(iv) prodrug for enhanced anticancer therapy

This study reports a strategy of combining a Pt(iv) prodrug and a ruthenium nitrosyl (Ru-NO) donor into a single nanoplatform {N-GQDs@Ru-NO-Pt@FA} in which the platinum(iv) prodrug is conjugated onto a photoactivatable NO donor (Ru-NO) through a covalent bond and the nitric oxide-releasing platinum...

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Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2019-03, Vol.7 (11), p.1867-1874
Main Authors: Shi, Shu-Wen, Li, Yan-Hui, Zhang, Qian-Ling, Yang, Shi-Ping, Liu, Jin-Gang
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
Cobalt
Covalent bonds
Folic acid
Graphene
Infrared radiation
Irradiation
Light
Light irradiation
Nitric oxide
Platinum
Quantum dots
Radiation
Ruthenium
Therapy
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cited_by cdi_FETCH-LOGICAL-c315t-e58f9f566930fe8358012d7f74b31c0e5b572e48b450d34e36063159d19b13403
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container_start_page 1867
container_title Journal of materials chemistry. B, Materials for biology and medicine
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creator Shi, Shu-Wen
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description This study reports a strategy of combining a Pt(iv) prodrug and a ruthenium nitrosyl (Ru-NO) donor into a single nanoplatform {N-GQDs@Ru-NO-Pt@FA} in which the platinum(iv) prodrug is conjugated onto a photoactivatable NO donor (Ru-NO) through a covalent bond and the nitric oxide-releasing platinum prodrug and folate groups are decorated on N-doped graphene quantum dots (N-GQDs). After cellular uptake of the nanoplatform, the platinum(iv) prodrug was reduced to an active anti-cancer Pt(ii) species inside the cancerous cells, and simultaneously, near-infrared (NIR) light illumination induced the release of NO, accompanied by a prominent photothermal effect. This nanoplatform is capable of targeting intracellular co-delivery of Pt(ii) and NO under 808 nm NIR light irradiation, accompanied by photothermal therapy, thereby leading to a significant synergistic therapeutic effect.
doi_str_mv 10.1039/c8tb02743a
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source Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)
subjects Cancer
Cancer therapies
Cobalt
Covalent bonds
Folic acid
Graphene
Infrared radiation
Irradiation
Light
Light irradiation
Nitric oxide
Platinum
Quantum dots
Radiation
Ruthenium
Therapy
title Targeted and NIR light-controlled delivery of nitric oxide combined with a platinum(iv) prodrug for enhanced anticancer therapy
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