COVID-19 and the Heart

Infection with the severe acute respiratory syndrome novel coronavirus produces a clinical syndrome known as 2019 novel coronavirus disease (COVID-19). When severe, COVID-19 is a systemic illness characterized by hyperinflammation, cytokine storm, and elevations of cardiac injury biomarkers. Here, w...

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Bibliographic Details
Published in:Circulation research 2020-05, Vol.126 (10), p.1443-1455
Main Authors: Akhmerov, Akbarshakh, Marbán, Eduardo
Format: Article
Language:English
Subjects:
Animals
Betacoronavirus
Biomarkers
Cardiovascular Diseases - etiology
Cardiovascular Diseases - physiopathology
Cardiovascular Diseases - therapy
Cell- and Tissue-Based Therapy
Coronavirus Infections - complications
Coronavirus Infections - drug therapy
Coronavirus Infections - physiopathology
Coronavirus Infections - therapy
Humans
Inflammation
Mice
Pandemics
Peptidyl-Dipeptidase A
Pneumonia, Viral - complications
Pneumonia, Viral - physiopathology
Pneumonia, Viral - therapy
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Summary:Infection with the severe acute respiratory syndrome novel coronavirus produces a clinical syndrome known as 2019 novel coronavirus disease (COVID-19). When severe, COVID-19 is a systemic illness characterized by hyperinflammation, cytokine storm, and elevations of cardiac injury biomarkers. Here, we review what is known about the pathophysiology of COVID-19, its cardiovascular manifestations, and emerging therapeutic prospects. In this rapidly moving field, this review was comprehensive as of April 3, 2020.
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.120.317055