Circulating Neuroendocrine Gene Transcripts (NETest): A Postoperative Strategy for Early Identification of the Efficacy of Radical Surgery for Pancreatic Neuroendocrine Tumors

Background Surgery remains the only treatment for the cure of pancreatic neuroendocrine tumors (PanNETs). Biomarkers to identify the completeness of resection and predict recurrence are lacking. Objective The aims of this study were to evaluate if the blood measurement of neuroendocrine gene transcr...

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Bibliographic Details
Published in:Annals of surgical oncology 2020-10, Vol.27 (10), p.3928-3936
Main Authors: Partelli, Stefano, Andreasi, Valentina, Muffatti, Francesca, Schiavo Lena, Marco, Falconi, Massimo
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Chromogranin A
Humans
Medicine
Medicine & Public Health
Neoplasm Recurrence, Local
Neuroendocrine Tumors - genetics
Neuroendocrine Tumors - surgery
Oncology
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - surgery
Pancreatic Tumors
Prospective Studies
Surgery
Surgical Oncology
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Summary:Background Surgery remains the only treatment for the cure of pancreatic neuroendocrine tumors (PanNETs). Biomarkers to identify the completeness of resection and predict recurrence are lacking. Objective The aims of this study were to evaluate if the blood measurement of neuroendocrine gene transcripts (NETest) was diagnostic of PanNETs, and whether NETest blood levels could identify complete resection. We compared transcript analysis with the biomarker chromogranin A (CgA). Methods This was a prospective, longitudinal, single-center study including 30 patients with a postoperative histological confirmation of PanNET. Blood for NETest and CgA was collected preoperatively and on postoperative day (POD) 1, POD5, and POD30. Transcripts were measured by real-time quantitative reverse transcription polymerase chain reaction and multianalyte algorithmic analysis (NETest; normal 
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-08425-6