Facile synthesis of magnetic core-shell nanocomposites for MRI and CT bimodal imaging

With the development of nanotechnology, nanocomposites have been used as bimodal contrast agents for magnetic resonance (MR) and computed tomography (CT) imaging. We have developed a facile method for the synthesis of iron oxide@bismuth sulfide magnetic core-shell nanocomposites. These bifunctional...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2015-09, Vol.3 (34), p.6905-6910
Main Authors: Zhu, Jing, Wang, Jiaqing, Wang, Xin, Zhu, Jingfen, Yang, Yanmei, Tian, Jian, Cui, Wenguo, Ge, Cuicui, Li, Yonggang, Pan, Yue, Gu, Hongwei
Format: Article
Language:English
Subjects:
Biology
Imaging
Iron
Magnetic resonance imaging
Nanocomposites
Sulfides
Synthesis
Tomography
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Summary:With the development of nanotechnology, nanocomposites have been used as bimodal contrast agents for magnetic resonance (MR) and computed tomography (CT) imaging. We have developed a facile method for the synthesis of iron oxide@bismuth sulfide magnetic core-shell nanocomposites. These bifunctional nanocomposites can be made water-soluble via PEG coating and present strong MRI/CT contrast enhancement. Evaluation of cytotoxicity by MTT assay shows that the nanocomposites have low cytotoxicity. The results illustrate that the nanocomposites have great potential as bimodal imaging agents for MR/CT.
ISSN:2050-750X
2050-7518
DOI:10.1039/c5tb00775e