In vivo multi-photon luminescence imaging of cerebral vasculature and blood-brain barrier integrity using gold nanoparticles

We report that time-dependent morphological changes of cortical vasculature, which would be associated with blood-brain barrier disruption, can be clearly visualized with high spatial resolution in a stroke mouse model using the multi-photon luminescence of long-circulating gold nanoparticles.

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2015-04, Vol.3 (15), p.2935-2938
Main Authors: Yoon, Hwan-Jun, Lee, Eek-Sung, Kang, Minseok, Jeong, Yong, Park, Ji-Ho
Format: Article
Language:English
Subjects:
Biology
Blood-brain barrier
Gold
Imaging
Integrity
Luminescence
Nanoparticles
Strokes
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Description
Summary:We report that time-dependent morphological changes of cortical vasculature, which would be associated with blood-brain barrier disruption, can be clearly visualized with high spatial resolution in a stroke mouse model using the multi-photon luminescence of long-circulating gold nanoparticles.
ISSN:2050-750X
2050-7518
DOI:10.1039/c4tb01759e