Indocyanine green-platinum porphyrins integrated conjugated polymer hybrid nanoparticles for near-infrared-triggered photothermal and two-photon photodynamic therapy

A type of polymeric nanoparticles loading indocyanine green and Pt(ii)-porphyrins (ICG-Pt-NPs) is constructed to achieve a synergistic effect of combined photothermal and two-photon activated photodynamic therapy. The nanoparticle core comprises the photosensitizer Pt(ii)-porphyrins (PtTFPP), and or...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2017-03, Vol.5 (9), p.1856-1862
Main Authors: Wang, Xiao-Hui, Peng, Hong-Shang, Yang, Wei, Ren, Zhao-Di, Liu, Xiao-Ming, Liu, Yuan-An
Format: Article
Language:English
Subjects:
Biology
Effectiveness
Irradiation
Lasers
Nanoparticles
Photodynamic therapy
Synergistic effect
Therapy
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Summary:A type of polymeric nanoparticles loading indocyanine green and Pt(ii)-porphyrins (ICG-Pt-NPs) is constructed to achieve a synergistic effect of combined photothermal and two-photon activated photodynamic therapy. The nanoparticle core comprises the photosensitizer Pt(ii)-porphyrins (PtTFPP), and organic semiconducting polymer (PFO) that acts as a two-photon antenna. Negative ICG molecules, an NIR-absorbing photothermal dye, can be loaded into the positively charged poly-l-lysine (PLL) shell of the polymeric nanoparticles via electrostatic interaction. In these carefully designed ICG-PtTFPP integrated nanoparticles, PtTFPP absorbs the photonic energy transferred by the PFO polymer under two-photon laser excitation at 740 nm to induce photodynamic cancer cell death, while ICG offers nanoparticles a strong photothermal performance under 808 nm laser irradiation. Compared with photodynamic therapy or photothermal therapy alone, the combined therapy had a significantly synergistic effect and improved the therapeutic efficacy with near-infrared irradiation.
ISSN:2050-750X
2050-7518
DOI:10.1039/c6tb03215j