Zinc-stabilized colloidal polyelectrolyte complexes of chitosan/hyaluronan: a tool for the inhibition of HIV-1 infection

Zinc( ii ) stabilized polyelectrolyte nano-complexes (PECs) of chitosan and hyaluronan (HYA) were designed as safe and efficient drug delivery systems. HIV-1 reverse transcriptase inhibitor tenofovir (TF) was quantitatively encapsulated and the particle interface could be functionalized in PBS with...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2016-01, Vol.4 (32), p.5455-5463
Main Authors: Wu, Danjun, Ensinas, Agathe, Verrier, Bernard, Primard, Charlotte, Cuvillier, Armelle, Champier, Gaël, Paul, Stephane, Delair, Thierry
Format: Article
Language:English
Subjects:
Chemical Sciences
Chitosan
Colloids
Drug delivery systems
Human immunodeficiency virus
Human immunodeficiency virus 1
Hyaluronan
Immunoglobulins
Material chemistry
Nanostructure
Polyelectrolytes
Polymers
Reduction
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Summary:Zinc( ii ) stabilized polyelectrolyte nano-complexes (PECs) of chitosan and hyaluronan (HYA) were designed as safe and efficient drug delivery systems. HIV-1 reverse transcriptase inhibitor tenofovir (TF) was quantitatively encapsulated and the particle interface could be functionalized in PBS with targeting proteins such as anti-α4β7 immunoglobulin A. Chitosan-HYA nanoPECs were non-cytotoxic on human peripheral blood mononuclear cells (PBMCs), within the investigated nanoparticle concentrations. A dose-dependent reduction of the HIV-1 infection of PBMCs co-cultured with the nanocarriers was observed. Even more interestingly, a synergistic effect was evidenced with the nanocarriers by comparing the IC 50 (50% inhibitory concentration) value of the aqueous TF solution (4.35 μmol L −1 ) with that of TF loaded nanoPECs (1.71 μmol L −1 ) and anti-α4β7 IgA functionalized TF/nanoPECs (1.01 μmol L −1 ). This effect could be attributed to the presence of zinc( ii ) in the formulation of the colloids. All these data establish that the zinc( ii ) stabilized chitosan-HYA nanoPECs can be potentially efficient and safe colloidal delivery system candidates for enhancing antiviral activities in the treatment of HIV infection and AIDS. Zinc( ii ) stabilized polyelectrolyte nano-complexes (PECs) of chitosan and hyaluronan (HYA) were designed as safe and efficient drug delivery systems.
ISSN:2050-750X
2050-7518
DOI:10.1039/c6tb00898d