Extracellular matrix-inspired assembly of glycosaminoglycan-collagen fibers

We report on the fabrication of fibers exclusively from extracellular matrix components by interfacial complexation with no use of any crosslinking agent. The obtained fibers may have different biomedical applications as they are flexible, cell adhere to and remodel them. Moreover, their stability a...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2017-05, Vol.5 (17), p.3103-3106
Main Authors: Carretero, Agatha, Costa, Diana Soares da, Reis, R. L., Pashkuleva, I.
Format: Article
Language:English
Subjects:
Assembly
Biology
Biomedical materials
Collagen
Complexation
Extracellular matrix
Ffibers
Fibers
Glycosaminoglycans
Interfacial polyelectrolyte complexation
Science & Technology
Stability
Sulfation
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Summary:We report on the fabrication of fibers exclusively from extracellular matrix components by interfacial complexation with no use of any crosslinking agent. The obtained fibers may have different biomedical applications as they are flexible, cell adhere to and remodel them. Moreover, their stability and thickness can be finely tuned by the sulfation degree of the used glycosaminoglycans. We acknowledge EU for the financial support under Grants CytoNanoHeal (ENMed/0001/2015), H2020-TWINN-2015- 692333-CHEM2NATURE and ERC-2012-ADG-20120216-321266 for the project ComplexiTE. A.C. is grateful to CAPES (Brazil) for providing her grant BEX: 12926-13/2. DSC and IP are thankful to the Portuguese Foundation for Science and Technology (BPD/85790/2012 and IF/00032/2013). ‡SupporLng InformaLon. The used reagents, cells and materials are described in the supporting information together with the respective experimental details. Data about optimization of the IPC fibers processing, their flexibility in a dry state and stability at physiological conditions are also provided in the supporting information.
ISSN:2050-750X
2050-7518
DOI:10.1039/C7TB00704C