Near‐infrared spectroscopy as a potential non‐invasive tool in the assessment of disease activity in vitiligo patients

Vitiligo is a common chronic depigmenting skin disease. We explored the utility of near‐infrared (NIR) spectroscopy in the identification of spectral changes associated with disease activity in vitiligo patients. In vivo spectral measurements were performed directly on the perilesional skin of 70 vi...

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Bibliographic Details
Published in:Experimental dermatology 2020-06, Vol.29 (6), p.570-574
Main Authors: De Bruyne, Sander, Speeckaert, Reinhart, Himpe, Jonas, Delanghe, Joris R.
Format: Article
Language:English
Subjects:
dermatology
disease activity
Infrared spectroscopy
near‐infrared
Skin diseases
spectroscopy
Spectrum analysis
Vitiligo
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Summary:Vitiligo is a common chronic depigmenting skin disease. We explored the utility of near‐infrared (NIR) spectroscopy in the identification of spectral changes associated with disease activity in vitiligo patients. In vivo spectral measurements were performed directly on the perilesional skin of 70 vitiligo patients. Relative intensities (second derivative) at 1139, 1344, 1646 and 1839 nm appeared to be significantly lower in the perilesional region of patients with active vitiligo compared with stable disease, while the intensity at 1884 nm seemed to be significantly higher. A classification model based on the spectral ranges around those peaks generated a correct prediction in 82.9% of the cases. In conclusion, we can state that NIR spectroscopy could have potential in the assessment of disease activity. However, large‐scale prospective studies are necessary to confirm our preliminary results.
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.14097