Utilization of biomarkers as predictors of skeletal muscle mitochondrial content after physiological intervention and in clinical settings

The measurement of mitochondrial content is essential for bioenergetic research as it provides a tool to evaluate if changes in mitochondrial function are strictly due to changes in content or other mechanisms that influence function. In this perspective, we argue that commonly used biomarkers of mi...

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2020-06, Vol.318 (6), p.E886-E889
Main Authors: Groennebaek, Thomas, Nielsen, Joachim, Jespersen, Nichlas Riise, Botker, Hans Erik, de Paoli, Frank V, Miller, Benjamin F, Vissing, Kristian
Format: Article
Language:English
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Summary:The measurement of mitochondrial content is essential for bioenergetic research as it provides a tool to evaluate if changes in mitochondrial function are strictly due to changes in content or other mechanisms that influence function. In this perspective, we argue that commonly used biomarkers of mitochondrial content may possess limited utility for capturing changes in content with physiological intervention. Moreover, we argue that they may not provide reliable estimates of content in certain pathological situations. Finally, we discuss potential solutions to overcome issues related to the utilization of biomarkers of mitochondrial content. Shedding light on this important issue will hopefully aid conclusions about the mitochondrial structure-function relationship.
ISSN:0193-1849
1522-1555
DOI:10.1152/AJPENDO.00101.2020