The expression of CD73 on pathological B-cells is associated with shorter overall survival of patients with CLL

CD73 is a membrane-bound enzyme that catalyzes the extracellular conversion of adenosine monophosphate to adenosine. Adenosine is thought to play a role in promoting tumor growth and survival together with suppressing the host immune responses, which contribute to the multistep process of tumorigene...

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Bibliographic Details
Published in:Neoplasma 2020-01, Vol.67 (4), p.933-938
Main Authors: Kicova, M, Michalova, Z, Coma, M, Gabzdilova, J, Dedinska, K, Guman, T, Bernatova, S, Hajikova, M, Giertlova, M, Veselinyova, D, Sarissky, M
Format: Article
Language:English
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Summary:CD73 is a membrane-bound enzyme that catalyzes the extracellular conversion of adenosine monophosphate to adenosine. Adenosine is thought to play a role in promoting tumor growth and survival together with suppressing the host immune responses, which contribute to the multistep process of tumorigenesis. Here, we studied the expression of this antigen in chronic lymphocytic leukemia (CLL). The expression of CD73 was analyzed by multiparametric flow cytometry on normal and pathological B-cells from peripheral blood and bone marrow samples from 71 patients with CLL. Pathological B-cells expressed significantly lower levels of CD73 than normal B-cells (p
ISSN:0028-2685
DOI:10.4149/neo_2020_190826N822