Lamin B2, Guardian of Cardiomyocyte Nuclear Division

Regenerative capacity is robust in the neonatal mouse heart but is lost during postnatal development when cardiomyocytes undergo cell-cycle arrest and polyploidization. In this issue of Developmental Cell, Han et al. (2020) show that Lamin B2, a nuclear lamina filament supporting cardiomyocyte karyo...

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Bibliographic Details
Published in:Developmental cell 2020-04, Vol.53 (1), p.5-7
Main Authors: Payumo, Alexander Y., Huang, Guo N.
Format: Article
Language:English
Subjects:
Animals
Cell Nucleus
Cell Nucleus Division
Lamin Type B
Mice
Myocytes, Cardiac
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Summary:Regenerative capacity is robust in the neonatal mouse heart but is lost during postnatal development when cardiomyocytes undergo cell-cycle arrest and polyploidization. In this issue of Developmental Cell, Han et al. (2020) show that Lamin B2, a nuclear lamina filament supporting cardiomyocyte karyokinesis, also facilitates cell division and cardiac regeneration. Regenerative capacity is robust in the neonatal mouse heart but is lost during postnatal development when cardiomyocytes undergo cell-cycle arrest and polyploidization. In this issue of Developmental Cell, Han et al. (2020) show that Lamin B2, a nuclear lamina filament supporting cardiomyocyte karyokinesis, also facilitates cell division and cardiac regeneration.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2020.03.016