In vitro controlled release of theophylline from metal-drug complexes

Two new metal-drug complexes constructed from non-toxic zinc and theophylline (TPL), an anti-asthmatic active drug, have been introduced into a release system based on matrices of hydroxypropylmethylcellulose (HPMC) and microcrystalline cellulose (MC). The release rate of TPL from the metal-drug com...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2013-08, Vol.1 (32), p.3879-3882
Main Authors: Wang, Hao, Hu, Tong-Liang, Wen, Rong-Mei, Wang, Qian, Bu, Xian-He
Format: Article
Language:English
Subjects:
Active control
Austenitic stainless steels
Biology
Coordination compounds
Diffusion
Theophylline
Transport
Zinc
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Summary:Two new metal-drug complexes constructed from non-toxic zinc and theophylline (TPL), an anti-asthmatic active drug, have been introduced into a release system based on matrices of hydroxypropylmethylcellulose (HPMC) and microcrystalline cellulose (MC). The release rate of TPL from the metal-drug complexes could be controlled by the amount of MC added, and the release mechanism changed from anomalous transport to Fickian diffusion.
ISSN:2050-750X
2050-7518
DOI:10.1039/c3tb20633e