A novel fluorescent probe for selective detection of thiols in acidic solutions and labeling of acidic organelles in live cells

A novel fluorescent probe, quinoline α,β-unsaturated diacid (QMA), as compared to its ester QME, was constructed and can selectively detect thiols in acidic solutions (pH < 7) via a H-bond activated Michael addition. Furthermore, labeling of lysosomes and cell imaging were achieved by the detecti...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2013-01, Vol.1 (4), p.438-442
Main Authors: Song, Qin-Hua, Wu, Qing-Qing, Liu, Chang-Hui, Du, Xiao-Jiao, Guo, Qing-Xiang
Format: Article
Language:English
Subjects:
Biology
Esters
Fluorescence
Marking
Materials selection
Organelles
Quinoline
Thiols
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Summary:A novel fluorescent probe, quinoline α,β-unsaturated diacid (QMA), as compared to its ester QME, was constructed and can selectively detect thiols in acidic solutions (pH < 7) via a H-bond activated Michael addition. Furthermore, labeling of lysosomes and cell imaging were achieved by the detection of biothiols in different domains of live cells.
ISSN:2050-750X
2050-7518
DOI:10.1039/c2tb00402j