NIR fluorescence labelled carbon nano-onions: synthesis, analysis and cellular imaging

The preparation of novel NIR fluorescent carbon based nanomaterials, consisting of boron difluoride azadipyrromethene fluorophores covalently attached to carbon nano-onions, is demonstrated. In addition, the analysis of the new nanomaterial is presented. The fluorescent nano-derivative properties ar...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2014-11, Vol.2 (42), p.7459-7463
Main Authors: Giordani, Silvia, Bartelmess, Juergen, Frasconi, Marco, Biondi, Ilaria, Cheung, Shane, Grossi, Marco, Wu, Dan, Echegoyen, Luis, O'Shea, Donal F
Format: Article
Language:English
Subjects:
Carbon
Cellular
Chemical compounds
Fluorescence
Imaging
Medicine
Nanomaterials
Nanostructure
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Summary:The preparation of novel NIR fluorescent carbon based nanomaterials, consisting of boron difluoride azadipyrromethene fluorophores covalently attached to carbon nano-onions, is demonstrated. In addition, the analysis of the new nanomaterial is presented. The fluorescent nano-derivative properties are customized such that their emission can be reversibly on/off modulated in response to pH, which is demonstrated in solution and in cells. The in vitro imaging of HeLa Kyoto cells is carried out and the cellular uptake of the carbon nano-onion NIR fluorophore conjugates is verified.
ISSN:2050-750X
2050-7518
DOI:10.1039/c4tb01087f