From protected trialkoxysilyl-peptide building blocks to bioorganic-silica hybrid materials

A straightforward method for the preparation of hybrid bioorganic-inorganic materials is reported. Common strategies to synthesize such promising materials require special surface modifications of silica followed by grafting of the organic moiety via chemoselective ligation. In this context, we set...

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Bibliographic Details
Published in:Journal of materials chemistry 2013-12, Vol.1 (47), p.6510-6515
Main Authors: Jebors, Said, Cecillon, Sebastien, Faye, Clément, Enjalbal, Christine, Amblard, Muriel, Mehdi, Ahmad, Subra, Gilles, Martinez, Jean
Format: Article
Language:English
Subjects:
Antifouling coatings
Antiinfectives and antibacterials
Biology
Chemical Sciences
Immersion coating
Material chemistry
Peptides
Porosity
Silicon dioxide
Strategy
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Summary:A straightforward method for the preparation of hybrid bioorganic-inorganic materials is reported. Common strategies to synthesize such promising materials require special surface modifications of silica followed by grafting of the organic moiety via chemoselective ligation. In this context, we set up a general and bottom-up strategy relying on modified peptides functionalized with a trialkoxysilane group. Used in mixtures with TEOS and a surfactant as the structure directing agent, these hybrid building blocks allow one step direct synthesis of bioorganic-inorganic hybrid materials. Two examples were chosen to demonstrate our general approach. (1) An antifouling surface was prepared by dip coating of a sol containing an antibacterial silylated peptide. (2) Organized mesoporous silica displaying a peptide catalyst in the pores was prepared in one step and tested.
ISSN:2050-750X
0959-9428
2050-7518
1364-5501
DOI:10.1039/c3tb21326a